In April 1995, the show was setting up a storyline in which one character planned to set off a bomb at the wedding of two other characters. When the Alfred P. Murrah Federal Building, in Oklahoma City, was destroyed by a bomb on April 19th, producers immediately canceled the storyline. They appeared at the beginning of one episode to explain their decision.
Agnes Nixon originally offered her creation to Procter & Gamble in the mid-1960s, but they passed. After Nixon's success with One Life to Live (1968) for ABC, they asked for another series, and Nixon dusted off the old script which had been tucked away in a desk.
In the opening credits there is a poem written in the photo album. It reads: "The great and the least, The rich and the poor, The weak and the strong, In sickness and in health, In joy and sorrow, In tragedy and triumph, You are All My Children.
In October 2008, the series debuted the couple of Reese Williams and Bianca Montgomery. This couple made history in American daytime television in several ways. They were groundbreaking for featuring the first same-sex marriage proposal, as well as the first legal same-sex wedding and marriage, on an American soap opera. In addition, the pairing's family is the first onscreen family made up of same-sex parents in the history of American daytime television.
During the summer of 1994, a story line centered around a destructive tornado hitting Pine Valley. Shortly after that aired, such a tornado in real life struck Bryn Mawr, Pa, the town Pine Valley was largely inspired by and based on.