An elderly woman wants to be young again. She has lots of money and enlists a mad scientist who works all day in the basement with his nuclear device to transplant brains atomically. Brought into the picture are three young women who will provide the body, once the process is perfected. One woman gets a cat brain transplant and runs around scratching people and screeching. Another is a victim of cat-woman and loses her eyesight. The third becomes the target for the transplant. Unfortunately, there are failed experiments running around the house, particularly a young woman who has no brain at all. She is just there to provide amusement. The old lady continues to bully the young women who ask to leave, but stay just because she tells them to (apparently, they need her to let them out of their contract and she will call immigration and get them sent back). When they finally act, it is too late. There is also an old lech who can't wait for the old lady to get a new body, but comes to realize that he is going to be left in the dust. He then becomes a possible roadblock, although the old lady is so mean spirited she doesn't seem to care. Nevertheless, the transplant does finally take place but with different consequences than the old lady had anticipated.
The biggest problem has to do with trust. The scientist works at the behest of the old woman, but seems to have his own agenda. He is annoyed by her constant meddling in what he is doing. He betrays here of course. So much of the movie is in anticipation of finally doing the transplant. We just can't get there and the ride is long and tedious.