- A young lady reporter helps a newspaperman in his search throughout Africa for the famous Dr. Livingstone.
- Jack Cameron, scientist and naturalist, is commissioned by the US government for a confidential mission to join Henry Morton Stanley on his expedition into Africa in search of Dr. Livingstone. Jack's mission is to attempt contact with the White Tribe, said to hold the secret of intensive cultivation, and study the properties of the mysterious octopus plant. In addition, Jack has a personal reason for going to Africa as his father went missing there years earlier. Ambitious young reporter Nadia Elkins learns of Cameron's secret mission and convinces her editor to permit her to leave for Africa to get the whole story. Once in Africa, Nadia manages to join Jack and Stanley as the expedition gets underway, but Nadia gets separated from the expedition when it is attacked by angry natives. As Stanley continues onward, Jack stays behind to find Nadia. Meanwhile, Reynard Lake, son of Nadia's editor, attempts to thwart Jack and Nadia and derail Stanley's expedition for his and his father's own nefarious reasons. In addition to having to deal with Lake's interference and attacks by randomly encountered specimens of deadly African wildlife, Jack and Nadia run afoul of local Arab slave traders. Stanley steadily continues in search of Livingstone, occasionally crossing paths with Jack and Nadia as they become increasing involved in their side adventures. Jack and Nadia are reunited with Stanley shortly after he encounters Dr. Livingstone at Ujiji, but then Nadia is abducted by the Arabs. Jack rescues her and they decide to continue their search for the White Tribe. Coming upon the village of the White Tribe, Jack and Nadia are captured and taken to a sacrificial cave. Just as Nadia is about to be sacrificed one of the village's priests intervenes. He is in fact Jack's long missing father, who then proceeds to preside over the marriage of Jack and Nadia. Stanley and Livingstone part company at Unyanyembe, Livingstone to continue exploring the African interior, Stanley to proceed to England to report his discovery of Livingstone, and Jack and Nadia returning to the United States.
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By what name was With Stanley in Africa (1922) officially released in Canada in English?
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