Hank's father dies. Despite the memories of his father floating to the surface, he doesn't want to go to the funeral. Meanwhile, he goes to bed with a hooker named Trixie, despite the fact he doesn't have enough money to pay her.
After Hank is arrested by the police and sent to prison, he meets record producer Lew Ashby, who asks Hank to write his biography, in the meantime, Charlie is fired after videos of him masturbating in the office are shown to his boss.
Mia's - that is, originally Hank's - book gets rave reviews, ironically better than any of the books published in Hank's name. Lew is having a party to which pretty much everyone is invited. Marcy has just come back from rehab and Charlie is planning to give her some time before announcing that he wants a divorce in order to be with Daisy. Annika, a Rolling Stone book critic has a scandalous theory about the true story behind Mia's book... And there's still more problems arising.
Following Karen's move to New York, Hank Moody does his best to raise his daughter Becca by himself. But being a single dad isn't easy, especially with Becca starting to question his authority more than ever. To make matters worse, Becca's new best friend Chelsea has a fondness for sex, drugs, and trouble. After a run-in with Chelsea's straight-laced mother Felicia, a teacher at the local university, Hank reluctantly accepts a dinner invitation. Hank does his best to tolerate the various academics at the party, but things get out of hand when Hank insists on having drinks with a professor. Meanwhile, Charlie moves back in with his soon-to-be-ex-wife Marcy as soon as they sort out the details of their divorce.
Hank and Becca attend the annual English Department Fall Mixer hosted by Dean Koons and wife Felicia. After flirtatious exchanges with student Jackie and Felicia, Hank finds himself consoling his jilted teacher's aide Jill, the best way he knows how. Meanwhile, Becca and Chelsea sneak away to discuss life, love, and psychedelic mushrooms. Charlie tries to coax Marcy into celebrating the first signing at the new agency, teen idol Rick Springfield.
Becca drags Hank to a trendy shopping boutique to pick out some more grown-up attire. But Hank isn't so sure he likes the "new" Becca's makeover. At work, Hank juggles sexual encounters with teacher's aide Jill and boss Felicia. And finally, in an attempt to figure out why talented writer Jackie is missing class, Hank drags Charlie to the strip club where she works. Unfortunately, temptation gets the better of Hank.
Becca flies to N.Y. to her mom while Hank's old best friend 'Zloz' comes to L.A. for the first time. His mission: to indulge in all kinds of depravity. Hank takes him to Sue's party, but that is just the beginning.
Karen is quickly onto what (or whom) Hank's been doing, but the actual problem is Becca, who isn't happy to hear that she is to move to N.Y. to live with her mother. A client of Charlie's turns out to be Marcy's fantasy. Runkle's Luck.
Hank has decided that he needs to get rid of the extraneous women in his life, and he intends to achieve it in one day. Unfortunately, the women might want to keep him. Meanwhile, Sue needs Charlie's help with her first client.
Jackie and two of her friends arrive to party. The next day, one of the girls is unconscious, and then Runkle & Rick Springfield arrive. They all have to hide when Jill suddenly arrives. And the knocks on the door just don't stop.
There's a call from the principal of the girls' school to Hank... and Stacy. Felicia has a revelation for Karen. Marcy is completely smitten by Rick and on top of that, Charlie has to provide him cocaine.
Karen, Becca and Marcy have a girls' night out. Since Charlie just got fired by Sue, Hank decides to have a boys' night out. The girls' night - uneventful. The boys' night - not so much. Then there's the morning after.
Felicia invites Hank and Karen for a lunch. When they arrive, they find Jill and Jackie there too - awkward. But it's the surprise guest who causes Hank to wail, "The worst day of my life!" And the worst is still to come.
As the Moodys at last prepare to move to New York, Becca tells Hank about an intimate coming of age experience she had. Hank's stunned when Mia shows up at the house unannounced, in town with her slimy boyfriend / manager PAUL for a book signing. Hank fails to prevent Mia and Paul from hatching a devious publicity stunt, forcing Hank to finally share the long-buried heartbreaking secret with Karen. Sue Collini gives Charlie a career opportunity of a lifetime, but Charlie must confront the fact that he might be losing Marcy for good.
Hank polishes off a day of flaky neediness with a creative meeting about his potential new movie that ends with him hiding in a starlet's bathroom and accidentally overdosing on booze and sleeping pills.
A sensational photo derails Hank's case and threatens to destroy his movie project until his sincere love for Becca rescues his career, while Karen resuscitates her ex-husband's relationship with his beautiful lawyer.
Forced by her relationship with Hank to recuse herself as his lawyer, Abby pitches the case to a senior partner on the golf course; Hank is dismayed by Karen's growing relationship with artist Ben; Marcy and Stu ask Charlie to help them pitch a TV project.
Hank takes a gig rewriting dialogue on a zombie sequel but threatens his job when he hooks up with a sexy woman with close ties to the film's female lead; Marcy tells Stu she's pregnant but not that the baby may be Charlie's.
Evicted from his apartment, Hank moves back in with Karen and Becca while he prepares for his trial and teaches his daughter to drive; while Karen's out on a date with Ben, Becca and Pearl steal the Porsche and wreck it.
A nervous Hank discovers that he's got good reason to panic when his trial turns into an all-out character assassination, with even friendly witnesses Charlie and Karen unable to portray him as anything other than a drunken, oversexed lout.
In the Season 4 finale, as Hank awaits sentencing, the lines between his real life and the movie based on his life blur as the film's star hits on his ex-wife and he feels stirrings of passion for the actress hired to play Karen.
Season five picks up a few years after we last saw Hank Moody. He's living in New York and has moved on. After the unceremonious dumping of his latest girlfriend, Carrie, Hank's looking for a ticket out of town. Charlie calls with just such a ticket - a job on the Left Coast. Back in LA, Hank and Charlie drop in on the now-married Marcy and Stu Beggs. Stu rushes Hank off to a meeting with megarich hip-hop mogul Samurai Apocalypse.
Hank receives an unwelcomed surprise in the form of Carrie, ex-girlfriend. When Karen and Becca show up to invite Hank to a dinner party, he has no choice but to bring Carrie along. While Stu, Marcy and Bates' sex talk leaves the Van der Moody's searching for the nearest exit, the party gets out of control when Carrie makes a realization about Hank.
Charlie's boyhood dream is realized and Hank's worst nightmare comes true when Samurai Apocalypse invites the boys on a ride-along with the Santa Monica Police Department. While at a crowded Venice restaurant, Richard Bates hits the bottle, prompting a return engagement of the "Glorious Mangina."
When Samurai Apocalypse hits a lyrical roadblock with his protégé, he calls on the best scribe he knows, one Hank Moody. Hank and Kali come together to imbibe, bare their souls, and write a song that takes Hank back in time.
It appears to be just like old times with Karen and Hank, but the moment is ruined by the arrival of a drunk Richard Bates. Hoping to save her from the misery of the situation, Hank quickly kicks Karen out of the house and takes off with Bates to piece together the events of the night before.
Hank finds himself stuck with the unpleasant task of reading Tyler's screenplay. Unfortunately for Hank, Tyler's hiding some talent under that head of hair. Even more unfortunate is the fact that the screenplay references Becca. Charlie and Lizzie's quadrilateral with Stu and Marcy heats up, but when MarStu's bedroom games hit too close to home for Charlie, it may be off to therapy for the four of them.
Hank, down an agent and best friend, finds reason to crash with his two favorite ladies -- Karen and Becca. There's still money to be made, so it's time for him to find new representation with Hollywood power agent Larry Levine. Lizzie's big break has arrived - a role in Santa Monica Cop, via a special favor from Stu Beggs. Charlie, distraught over his personal losses, seeks comfort from Marcy.
Hank has finally overstayed his welcome at the house of Karen and Richard Bates, so it's time to hit the road. But not before one last stop at Malibar, where he runs into Lizzie, who uses her newly acquired acting chops to lure him back to the Runkle Manor. Once there, Hank is surprised by everyone he loves and loathes - Karen, Becca, Charlie, Marcy, Stu, Bates and his creepy sponsor, Gabriel. Even Samurai Apocalypse and Kali show up. It's not a party until someone gets hurt. Luckily for these party-goers, Hank has it in him for one final run-in with Tyler.
Hank hits the local watering-hole, only something's amiss. Not only does Mr. Moody find himself surrounded by shadowy figures, but the bartender is an old, departed friend. Is Hank dreaming or has he finally made it to hell? Next it's onto the set of Santa Monica Cop where Sam's jealousy - and fondness for firearms - gives Charlie an opportunity to show just how much he loves his best friend and number one client. Later, Hank's ex-girlfriend surprises him with a way for them to be together forever.
Hank Moody narrowly survives the aftermath of his scorned ex-lover Carrie. Charlie takes Hank to see Atticus Fetch, a rocker who is interested in turning "A Crazy Little Thing Called Love" into a Broadway show.
Hank reluctantly heeds the advice from his family and friends, but Faith, muse to many-a-rock-star, may be his light at the end of the tunnel. Marcy loses her resolve with Stu, while Karen lands a new job.
Ken discovers Charlie's secret. Atticus sends Hank and Charlie on a hunt, so they enlist the help of Hank's rehab partner Faith. Marcy makes a decision about Stu that is influenced by her man-hating spiritual guide, Ophelia Robbins.
Atticus throws a party. Faith provides the girls, The Dealer provides the recreation, and Hank's old friend provides the entertainment. Hank gets a taste of his own medicine with Karen. Atticus tries to recreate rock'n roll folk lore with one of his biggest fans, while Charlie reunites with The Widow.
Hank and Faith join forces to track down Atticus. Surprisingly, Becca is the only person who can really help. Marcy's outing with Ophelia leaves her a little tied up. Charlie's response to a curious message reveals the true feelings between the two exes. Karen makes a revelation about Becca.
The day finally comes, can Marcy and Charlie go through with Stu's offer? Hank confronts his feelings about Becca's wedding and makes the difficult choice between spending his future with Julia or Karen.