Izzie and Cristina are assigned a close-to-brain-dead John Doe who may be a viable candidate for organ donation, and helpful to George's patient, who needs a new liver. Meanwhile, Meredith and Alex butt heads over a patient of their own.
Alex uses Izzie's modeling against her, and her last ad causes a patient to reject her care. Meredith finds parallels between a patient and her mother, and Christina must deal with a hospital-savvy patient.
Meredith worries she did something wrong during a heart bypass, an error in a past procedure is discovered, putting a staff member's conduct under scrutiny, while a party thrown by Izzie to introduce her boyfriend becomes a fiasco.
A woman with a massive tumor is admitted, with all the surgeons required to scrub in. In their absence, Meredith is assigned a patient with Parkinson's and, because Alex's pager is not working, Izzie is left in charge of the floor herself.
Izzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
Meredith wants to learn more about Derek, but he remains cagey. Meanwhile, a supposedly psychic patient proves bothersome, Alex must convince a young girl to agree to a life saving operation, and Cristina is conflicted about her pregnancy.
George discovers he has syphilis, and it soon emerges that the disease is rampant among the hospital staff. Suspicious about a patient's death, Izzie and Cristina perform an unauthorized autopsy, and Richard requires an emergency operation.
A family is admitted after being involved in a car crash, but there is more to them than meets the eye. Meanwhile, Bailey and her team deal with a strange case, and relationship woes plague Meredith, Cristina and George.
Cristina is determined to get back to work, and despite not being fully recovered, she manages to crack an odd case. Meanwhile, Addison offers to help Bailey with a complicated surgery, and Alex receives important news.
A storm rages, causing power outages and jamming the elevator, trapping George and Alex inside with a vulnerable patient. Meanwhile, Meredith and Derek arrange a religious ritual for a young woman, and Cristina deals with an unusual case.
A train wreck brings in multiple casualties, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his mojo a disheartening experience, and Cristina searches high and low for a missing appendage.
Derek reluctantly attends marriage counseling with Addison, while Meredith, Izzie and Cristina steal a patient with an unusual problem. Alex helps a young patient gain her independence, and Cristina thinks Bailey knows about her and Burke.
Friends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.
Thanksgiving sends the occupants of Meredith's house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner to which it appears no one is coming.
Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
The mother of the quints blames herself. Meanwhile, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina takes care of an inmate desperate to stay at the hospital.
Christmas hits Seattle, with Izzie caring for a man who fell from his roof while hanging decorations. Meanwhile, Cristina helps perform a heart transplant on a depressed boy, and George has to contend with the family from Hell.
Izzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.
Meredith must choose between her dog and her roommates. Meanwhile, George deals with an elderly patient who has outstayed her welcome, Bailey's pregnancy has complications, Alex gets his exam results, and Richard has a strike on his hands.
The nurses are striking, and George refuses to cross the picket line. The interns are surprised by Bailey's seemingly immature replacement, Izzie connects with a pregnant girl, and an elderly woman's plight pushes Meredith to the limit.
While the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.
Derek and Addison are shaken by the arrival of a figure from their past. Meanwhile, Burke learns Cristina's secret, Izzie deals with a very unusual case, Meredith delves into her family's dirty laundry, and George pours his heart out.
Cristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.
Superstition strikes, with the interns convinced a series of deaths will occur. A complication from the LVAD surgery puts Denny in the OR, Cristina plans to make George move out, and Richard's old AA sponsor is admitted for treatment.
Cristina is desperate for George to move out of the apartment, while Izzie is jealous of Callie's relationship with him. Meanwhile, Cristina and Richard are rivals in a surgery seminar, and Meredith discovers a secret about her father.
Meredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
The victims of a serious car accident are admitted, with every surgeon required to help. Meanwhile, Callie's forwardness grates on Izzie, Addison makes Alex suffer, and Derek takes his frustration out on Meredith.
Richard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
Everyone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
Izzie copes with her grief by baking furiously, and George has to deal with an obstinate patient. Meanwhile, Meredith must choose between Derek and Finn, Addison drowns her sorrows in alcohol, and Cristina meets Burke's difficult mother.
Izzie returns to the hospital, but finds it difficult to go inside, and George is tired of Callie's presence at home. Meanwhile, Addison cannot seem to get rid of Mark, and Cristina tries to cope with caring for Burke.
Meredith becomes a patient, and Derek and Addison are equally angry at Richard for allowing Mark to join the staff. Meanwhile, Izzie receives a visit from Denny's father, and Burke is plagued by doubt over his ability to return to surgery.
Izzie returns to the hospital under probation, and George tries to make amends with Callie. Meanwhile, Cristina's deletion of Bailey's name on Burke's OR board makes her assume he is against her, and Derek's irritating sister Nancy visits.
Derek, George, Alex, Burke, Richard, Joe and Walter go on a camping trip. Meanwhile, Meredith assists Mark with gender reassignment surgery, Izzie avoids discussing her grief, Addison works with Callie, and Cristina feels Bailey's wrath.
George must deal with his family's presence when his father is admitted. Meanwhile, Burke's secret is almost out, Alex tries to get close to Izzie again, and Richard comes to a decision about his marriage.
A traumatic car accident fills the ER. Cristina has a crisis of conscience about her deceptive teamwork with Burke, Izzie pushes the boundaries of her probation, and Callie tries to explain herself to George.
Bailey is adamant that Burke and Cristina should be punished, Derek doubts his abilities, Izzie tries to take a stand against Mark's patronizing behavior, and Meredith deals with family in two very different ways.
As George's father's surgery approaches, he begins to realize how serious his condition is. Meanwhile, Izzie has to prove to Bailey that she is ready to scrub in on a surgery, and Meredith keeps running into her father.
George deals with his grief, Cristina and Burke continue to ignore each other, Addison avoids Alex, and Izzie decides to help Bailey with a project. Meanwhile, Richard makes a decision which sends all the attendings scrambling.
A toxic patient wreaks havoc. Meanwhile, Bailey opens the free clinic, but the lack of patients makes Izzie question her investment. Meredith's mother is admitted again, and Cristina makes Burke wait for an answer.
The interns each react differently to a mass-casualty incident. Meanwhile, George crosses the professional line with Callie, Cristina asks Burke to keep quiet about their engagement, and Richard dons a new hairstyle.
Izzie fights to save her patient's life, George searches for the son of his patient, and Alex has to contend with the relatives of victims. Meanwhile, Meredith is unconscious underwater, with Derek her only hope.
An unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
A Korean war veteran with a bullet lodged in his shoulder is admitted. Meanwhile, tensions escalate between Izzie and George, Callie reveals a big secret, Cristina contends with an old flame, and Alex continues to work with the Jane Doe.
The attendings face their board interviews. Meanwhile, Izzie seems to be the only one who remembers the night before, Derek is overly protective of Meredith when Mark offers her a surgery, and Callie's father pays a visit.
Meredith deals with her over protective stepmother, Cristina is caught between Burke and Marlow, and Derek fights to become Chief. Meanwhile, Alex continues the search for Jane Doe's identity, and Izzie's past comes back to haunt her.
The Chairman of Seattle Grace's board of directors is admitted, and the attendings vie for his favor, while the interns study for exams. Izzy and George are reminded of their infidelity, and Burke presses Cristina about wedding plans.
Addison heads for warmer climes to figure things out, Meredith's stepmother visits the clinic, Cristina's perfect wedding is challenged when she and Burke's mothers visit, and Izzie tries to talk to George.
Addison is pulled into the case of a high-risk surrogate mother, Meredith's stepmother develops a complication, Izzie struggles with George's decision, and Ava has surgery which may restore her memory.
The interns face their first year medical exams. With the interns busy, the attendings must do their own legwork, Burke appoints a new best man, Cristina writes her vows, and Callie grows suspicious of George and Izzie.
The wedding day arrives. Richard chooses the new Chief and Chief Resident, the interns receive their exam results, Callie drops a bombshell on George while Izzie pours her heart out to him, and Burke makes an important decision.
Callie hides in her office, frustrating Bailey who's itching to teach someone. Elsewhere, age becomes the theme as Izzie tries to convince 'Really Old Guy' he shouldn't die, Webber and Sloan set out to prove they're not too old to learn a new technique, and Karev is saddled with an intern who's past his prime.
Bailey crosses the line when the guy she had a crush on in high school shows up in the ER during an onslaught of high school students involved in a bus crash. The Grey sisters run and hide when their father shows up drunk, while Derek tries to get back into the dating scene with another doctor and Cristina tries her best to get back into Hahn's good graces.
Tragedy abounds for everyone at Seattle Grace as they all continue in efforts to get the paramedic out of the overturned ambulance, stop the bleeding of a man who won't quit, and a bigot with a Nazi tattoo on his stomach. On the personal side, Rebecca returns to spend time with Alex, Miranda's husband finds it harder to wait for her while she's in surgery, and Cristina still tries to get on Hahn's good side, even though Bailey has put her elsewhere.
Addison is not prepared for all the changes that greet her upon her return to Seattle Grace for a specialized surgery, Meredith and Derek begin their clinical trial, Izzie feels left out, and Karev is confronted with an unexpected announcement.
A surgical team battles the clock as they try to save a boy encased in cement, Karev's situation with an ever-disintegrating Ava brings back painful memories that interfere with his judgment, Derek and Meredith have one last chance at their clinical trial.
Meredith and Derek are at odds over whether or not to continue with their 13th clinical trial patient and the doctors lift the final critical pieces of cement from the young boy's body. Meanwhile, Alex rushes Ava into the hospital and is forced to confront the reality of her condition.
Meredith and Derek find that "happily ever after" isn't as easy as they hoped, Cristina finds interest in a military doctor, and the Chief is surprised to hear that Seattle Grace is no longer ranked as a top-tier teaching hospital.
As a group of best friends deal with the aftermath of their car crash, Dr. Torres takes the lead on a groundbreaking course of treatment for one of the patients. Meanwhile, Major Hunt starts to irritate other attendings with his presence in the hospital.
Bailey's dream of a domino surgery is scuppered when one of the donors learns of her husband's affair, and Meredith is insulted when she gets no credit for the procedure she and Derek worked on together.
Derek has trouble with objectivity concerning his death row patient, Cristina and Meredith continue their feud, Izzie confides her problem to Alex, and the Chief faces what's become of his life's work.
Cristina carries on an intense flirtation with Owen, Derek gets advice from everyone on how to propose, Izzie gets some tests done, and Bailey's promotion may stand in the way of a new career possibility.
Owen runs into someone very special from his past. Izzie employs her fellow doctors in a medical game made to help teach the interns. Naomi, Sam and Addison rush Archer to Seattle Grace and meet with Derek and Mark to save his life.
Derek's malpractice deposition reveals an unhappy statistic, the interns finally diagnose 'Patient X', Karev stands up to two attendings to save a band geek, and when Webber shuts Miranda out completely she makes a call.
Sloane's facial transplant fades to the background as the interns begin squabbling, Bailey's attempts to reach Derek unexpectedly clear surgeons from the hospital, and Cristina juggles her first solo surgery with treating a resistant Izzie.
Izzie bites off more than she can chew on her first day of chemotherapy, Mark and Derek are forced to work on the same patient, Meredith's plans for a simple wedding take a turn, and Karev finds himself split between worry over Izzie and excelling as a resident.
A car crash involving students going to their college graduation takes its toll on the residents in the ER, Derek's wedding gift is uniquely suited for Meredith - even if the oversight is not. Meanwhile, Denny's return has Derek and Bailey searching for the cause, and the results will change the outcome of the day.
Izzie is torn over whether to have Derek's proposed brain surgery. A soldier on medical leave asks for a radical operation so he can return to active duty. The Chief tries to lure Bailey back to general surgery with a new toy, and Mark shifts into high gear with major life changes.
Covering days one through 13, everyone at Seattle Grace fights to save Izzie and George's lives and then deals with the aftermath. Elsewhere, Hunt treats a double amputation, and Arizona has a teen with painful growth spurts.
Thatcher is hospitalized with liver failure, and Meredith fights anger and guilt while deciding her responsibility. Sloan treats an octogenarian who wants an implant. Izzie's interference in Hunt's cancer case may have deadly consequences.
After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace residents defend their actions in an effort to save their jobs.
When Isaac, the hospital lab tech, has an inoperable tumor wrapped around his spine, he turns to Dr. Derek Shepherd to do the impossible, and Derek tests the Chief's authority when Richard objects to moving forward with the risky surgery.
A generous donation is offered to Seattle Grace by the parents of Arizona's 10-year-old patient. When his condition worsens, however, she finds herself with a conflict of interest. Meanwhile, Cristina tests her boundaries with Owen at the hospital and, adding insult to injury, Alex is left with all of Izzie's hospital bills to contend with.
When Owen recruits his fellow Iraqi War vet, Dr. Teddy Altman, as the new cardiothoracic surgeon, Cristina questions Teddy's abilities in the OR and the nature of their past relationship. Meanwhile Izzie returns to Seattle Grace with her high school mentor seeking treatment for his dementia, and the stress of Richard's responsibilities, post-merger, are taking their toll.
As Thanksgiving, Christmas and New Year's pass, Miranda is visited by her father, William, who disapproves of her choices in life; meanwhile, Mark and Lexie must cope with the shocking arrival of a woman from his past, and Thatcher Grey questions the Chief's recent behavior as Meredith comes to his defense.
Mark flies Addison to Seattle to help with a difficult procedure on his pregnant daughter, Sloan. Owen questions Teddy's motives when she assigns Cristina the lead on a complicated surgery, and Derek's suspicions are raised when the Chief recruits Meredith to assist with a high profile operation.
After learning of Richard's drinking problem, Derek confronts him for the sake of his friend and the hospital, Izzie returns, hoping to reconcile with Alex, and tensions run high between Teddy, Cristina and Owen in the aftermath of Cristina's startling confession.
An intra-operative crisis casts a shadow over Derek's first day as interim chief, Owen's influence worries Cristina, Karev's first pediatric surgery case turns out to be more than babysitting and Webber resents the decision he must make.
It's Valentine's Day and the doctors must treat dozens of injured people after the roof collapses at a popular romantic restaurant; Derek tries to manage his busy schedule as Chief of Surgery; Meredith wrestles with her new duties as the Chief's wife; and Mark and Callie team up to convince Sloane to do the right thing for her baby.
In his new role as Chief, Derek restores the hospital lecture series, and several attendings present to the group pivotal surgical cases from their pasts: Bailey reflects on how shy she was as an intern until getting advice from Webber, Callie looks back on a polio case, and Richard recalls a case in which he and Ellis worked on a patient diagnosed with AIDS, known in 1982 as GRID.
When Avery's grandfather comes to the ER, Webber's wish for a stress-free first day back is lost after the surgeon requests an awake surgery. Elsewhere, Cristina and Teddy attempt a hand-me-down lung transplant for a cancer survivor.
A patient who needs an extremely difficult surgery comes to Seattle Grace, and it's Richard and Owen who vie for the opportunity to tackle it. But the decision lies in the hands of Derek, who deems that Owen should take on the surgery, leaving Richard bitter. Meanwhile, Bailey deals with her own personal struggles when she nervously prepares for another date with Ben.
When Teddy's patient seeks to end treatment and her life, she turns to Hunt for help. The situation triggers Hunt's memories of his life at war and his past relationship with Teddy. Meanwhile, Callie and Arizona have a difference in opinion on what their future holds, and Richard tries to adjust to his role as a surgeon.
Sloan returns to Mark's apartment, just as she's going into labor, and Teddy, Mark and the still-fighting Callie and Arizona are there to help with the birth and to get Mark through his grandson's pending adoption. Meanwhile Teddy sees Derek's invitation to illustrious cardiothoracic surgeon Tom Evans' as a threat to her future employment at the hospital, and the team work on a crab boat captain who has been stabbed with a giant shark hook.
Bailey preps the team with mandatory sensitivity training prior to admitting a 700-pound patient with compounded medical issues, and the case proves to be challenging. Meanwhile Derek has to come face to face with a former patient's husband in a wrongful death deposition, and spending time with a heart patient's daughter opens up some old wounds for Cristina.
An elderly patient admitted into the E.R. for a heart condition sees a familiar face, a long lost love who happens to be in the E.R. as well for a fractured arm, and the staff find themselves caught up in their love story. Meanwhile, Karev treats a troubled teenage patient whose parents brought her in for schizophrenia, and Meredith can't help but tell Cristina about her suspicions of Owen -- which inevitably messes with Cristina's head.
After weeks of concealing the fact she was pregnant and miscarried, Meredith at last tells Derek and is finally cleared to return to her surgical duties in the wake of the hospital shooting spree; Cristina experiences post-traumatic stress disorder in the midst of an operation; and Bailey refuses to let Alex operate until he agrees to have the bullet in his chest removed.
When Derek receives an unexpected and unwelcome visit from his estranged sister, Amelia, issues between the siblings -- both past and present -- come to the surface; the Chief tries to help Alex when he notices that he's refusing to use the elevators after his near-fatal shooting; and Meredith and Derek continue their efforts to ease Cristina back into surgery after her post-traumatic stress.
Things are hostile on all fronts when a visit to the obstetrician results in some disturbing news for Meredith and Derek and Lexie loses it when she notices Meredith and April getting closer. Meanwhile, a car crash brings in multiple traumas and Jackson tries using his physical attributes to get ahead in the operating room, while Cristina's self-doubt carries outside of the hospital and into her house-hunting with Owen.
As part of their training, the Chief puts Seattle Grace's residents -- including Meredith, Cristina, April and Jackson -- in charge; meanwhile, Derek, Callie, Owen and the other attending surgeons compete for a million-dollar grant.
A documentary film crew visits the hospital six months after the shooting to document the road to recovery for doctors and patients. The camera lenses follow Derek, Owen, Mark & Callie as they ambitiously perform a rare arm transplant surgery, Meredith helps Cristina put on a brave face for the cameras, and Bailey's patient, Mary, returns for her surgery -- which marks the first time they've all seen of each other since that fateful day.
The residents are pushed to their limits when Owen puts them through a rigorous trauma certification drill; meanwhile, Cristina is also tested when left alone to monitor a very ill lung transplant patient.
Top security measures go into place as a team of doctors, led by the Chief, try to save the life of a major political figure from the Middle East. Meanwhile Cristina decides to finally decorate her new place and throw a housewarming party, and Alex shows up late from a weekend getaway to his first day of rounds with the new Pediatrics Attending, Dr. Robert Stark.
Derek lands the grant he needs for his clinical trial and all the attendings take him out to Joe's Bar to celebrate, but they get a surprise when they see someone they know already at the bar. Meanwhile, Meredith and Alex have to fend for themselves during the night shift with a nine-year-old patient who's experiencing post-surgical complications and his very pushy mother.
Despite Meredith's objections to the idea, a concerned Derek takes Cristina on a fishing trip in order to get away from it all, while Teddy, feeling directionless without Cristina, directs all of her efforts and compassion towards a dying patient who lacks the proper insurance to seek medical treatment.
News of the incoming mass causalities after a gunman opens fire at a local college hits the staff hard when they must spring into action, even while their own wounds are still fresh; and Arizona does not receive a warm welcome home at the hospital.
Arizona seeks Mark's advice as she tries to reconcile with Callie, who has big news of her own; Teddy must make a key decision for Henry during his surgery; and on the same day the residents receive a new crop of interns, the Chief announces he is looking for a new Chief Resident.
Thatcher Grey, Meredith and Lexie's father, returns to Seattle Grace with stomach pains and a new, twenty-something tattooed girlfriend, Danielle. Meanwhile, Alex clashes with the new OB, Dr. Lucy Fields, over a patient and Mark places Jackson on his service in exchange for information on Lexie.
Meredith, looking to prove she is Chief Resident material, learns that anything and everything can happen in an hour's time when she steps up to run the ER for a night; meanwhile, Bailey sneaks off with Eli and gets into a little mischief, and everyone is surprised when the Chief's wife, Adele, shows up as one of the ER patients.
Meredith must choose between her fertility treatments and her eyesight when she begins having trouble seeing, Mark makes it clear to Callie and Arizona that he takes his role as father-to-be very seriously, and April discovers there's more to Dr. Stark than first appears.
Richard is desperate for Derek and Meredith to accept Adele into their Alzheimer's trial, but will Adele stand in her own way? Meanwhile Mark and Arizona have conflicting ideas of the kind of baby shower Callie wants, Teddy is freaked out when Henry has another health complication -- leaving them both a little exposed -- and the competitiveness amongst the residents for the Chief Resident position is amplified when Richard receives the green light for his diabetes clinical trial.
In a series first, the music that has been at the heart of the show and been beloved by fans comes to life for Grey's Anatomy: The Music Event. A cataclysmic event rattles the doctors of Seattle Grace to the core, as Callie, on the verge of an enormous life-changing moment with Arizona, envisions her hospital and friends as it has never-been-seen before. "Chasing Cars" (Snow Patrol), "How to Save a Life" (The Fray) and "The Story" (Brandi Carlile) are among the songs performed by the cast.
Everyone pulls together to help Callie and baby Sofia on their painstaking journeys to recovery in hopes of allowing mother and baby to finally meet; the sudden death of a clinical trial patient has Derek proceeding with more caution while Meredith makes a calculated and risky move; Alex treats a cranky old rich woman dying of cancer and gets an idea for a grandiose endeavor that is sure to get him the Chief Resident spot; and Teddy is pleasantly surprised by the return of a familiar face.
As Callie and Arizona's wedding approaches, the couple quickly realize that the day they've been looking forward to is not turning out the way they'd envisioned. Meanwhile Alex continues to make the other residents jealous as he appears to be the top contender for Chief Resident, Meredith and Derek make a decision that will change their lives forever, and Dr. Perkins presents Teddy with a very tempting proposition.
As the official Chief Resident interviews begin, everyone steps up their game in the hopes of impressing Owen. Meanwhile, Meredith anxiously prepares for her first interview with the social worker and Cristina fights for a shot in the operating room.
News of Meredith and Derek's unsteady relationship raises a red flag for Zola's adoption counselor; Alex quickly realizes that he has become the outcast of the group after ratting out Meredith; and Cristina makes a tough decision regarding her unexpected pregnancy. Also, Chief Webber brings Henry in for a last minute surgery, alarming Teddy.
While Derek prepares to operate on a tumor deemed entirely inoperable, Hunt pressures Meredith to declare a specialty. As Cristina and Teddy try to steal a prized cardio surgery, the doctors celebrate Richard's 10,000th surgery.
On Valentine's Day Lexie volunteers to watch Zola for Meredith and Derek; Callie plans an evening for Arizona; and Ben shows Bailey how much he cares. Meanwhile, Christina and Owen drift farther apart despite the fact that he saves her when a car crashes into the hospital. Meredith and Bailey treat a woman who has headaches and seizures. Webber and Lexie treat a man who was hit by a car during a fight with his girlfriend. Alex treats a 10-year-old girl who has a severe reaction to peanuts when her boyfriend gives her a Valentine's Day gift.
In a final attempt to save Erica's life, Amelia arrives at Seattle Grace to beg Derek for help with the gliosarcoma case; Cristina and Owen engage in heated arguments during marriage counseling; Alex realizes that in order to be a good doctor, he'll need to improve his people skills; and Meredith is given a chance to shine when a man enters the ER after getting his hand stuck in meat grinder. Meanwhile, the residents continue to study for their upcoming oral boards.
As Adele's condition continues to deteriorate, Richard considers altering their living situation; an explosion at a local coffee shop results in a busy day in the ER for the doctors; Callie takes Meredith under her wing by helping her study for her boards; Lexie joins Arizona and Alex in peds, as they continue to care for intern Morgan's premature son; and when Jackson snaps at a patient, Mark encourages him to find ways to relieve his stress. Meanwhile, Cristina lets her suspicions get the best of her.
Derek encourages a hesitant Meredith to work with him again in neurology; Jackson's mother, Catherine Avery, returns to Seattle Grace with a urology fellow and develops an interest in Richard; and Cristina becomes increasingly suspicious of Owen's every move. Meanwhile, Alex tries to deny the fact that Morgan may be falling for him.
A pet lion on the loose gives the hospital some fierce injuries to deal with. Meanwhile, Cristina continues to ignore Owen, Lexie reconsiders her feelings for Mark, Callie has to face Arizona's romantic past with other hospital staff, and Alex starts to feel uncomfortable about his relationship with Morgan.
Grey, Bailey, and Webber work on a multi-organ transplant but run into some barriers when Dr. Sloan, the temporary Chief, orders them to cancel the surgery. Meanwhile, Cristina and Owen spend the day at home, working through their marital problems.
While the hospital becomes the center of attention as the victim of a famous kidnapping case is brought to the hospital, the fifth years take their placement interviews. Meanwhile, Adele Webber's memory continues to deteriorate, forcing Richard to reconsider their relationship.
As the fifth-years head off to San Francisco to take the most important exam of their lives there are some surprises along the way; Owen and Teddy continue to fight back at the hospital; Mark and Lexie reconnect; and Tommy's condition worsens.
Six hours after their oral boards, the fifth years relive their answers and worry about their chances. Back at the hospital, Bailey has to woo potential candidates for the hospital and Mark is startled when Julia makes a proposal about their future.
Before the Seattle Grace doctors head to Boise to take part in an operation on conjoined twins, the Attendings pressure the 5th years for final decisions on their posts next year. Meanwhile, Arizona must face the reality of her friend's condition and Ben tries to get Bailey to go on a special lunch date.
Months after the plane crash, the doctors at Seattle continue to try and find a new sense of normalcy. With a new set of interns to put through the ringer, the new fellows and attendings get used to their roles while Cristina adjusts to her new life in Minnesota. But the life of one doctor hangs in the balance and it's clear that Seattle Grace Mercy West is not the same.
The survivors of the crash are presented with a settlement offer, forcing them to choose between putting the incident behind them or investigating the true cause. Meanwhile, Jackson and April struggle to work with each other, Bailey is annoyed by the new attendings' behaviors, Callie struggles to communicate with Arizona, and Cristina learns to work with her new colleagues in Minnesota.
As Cristina begins to make new "friends" in Minnesota, Meredith struggles with whether or not to tell Derek about an extremely rare case she is working on. Meanwhile, Arizona begins work with her new prosthetist and tensions flare around work when Jackson's mother comes into town.
Split between Meredith in Seattle and Cristina in Minnesota, this episode shows each surgeon tackling an incredibly challenging surgery. Meredith must juggle work and parental obligations while Cristina is caught between Dr. Thomas and Dr. Parker.
Cristina's return to Seattle proves to be awkward when she and Owen must face each other again. Meanwhile, Jackson and April continue to try and negotiate their relationship, Jo deals with a perplexing case, and Bailey attempts to get Arizona into the hospital. Then, the survivors of the crash are shocked with new information about the cause of the crash.
It's Arizona's first day back at work and Callie tries to keep things as normal as possible for her. Meanwhile, Bailey argues with Ben over wedding plans and Cristina and Owen continue to struggle with their relationship while Owen faces his first set of meetings about the plane crash.
In an intern-centered episode, Jo and Alex work closely together and Jo discovers she has a certain image. Meanwhile, Meredith's intern is forced to find a donor nerve for Derek's hand and Cristina pits two of her interns against one another in competition for time in the OR.
As a jittery Bailey prepares for her wedding, Meredith and Derek disagree on whether or not to go through with the nerve transplant from Lizzie. Then, Cristina learns of the real reason behind Owen's plea for a divorce and Jo finds herself in trouble when she accuses Alex of mishandling her training. Then, a last minute emergency changes everything.
As Bailey puts her wedding on hold to tend to Adele, a biker gang floods the hospital with injuries for all the other doctors to tend to. Meanwhile, Cristina and Owen make a final decision about the divorce and Callie and Arizona try to reconnect.
The survivors receive a final verdict about the plane crash. Meanwhile, Derek continues to undergo rehabilitation on his hand, Cristina and Owen enjoy their new relationship with each other and Richard tried to avoid Catherine's advances.
Arizona is grappling with the pain of Phantom Limb when a consultant arrives at the hospital to begin investigations. While Derek embarks on his first major surgery, Meredith faces her biggest fear as she experiences pregnancy mood swings.
While Derek and April try and find a way to save the ER, Cristina and Leah struggle to keep a patient alive while respecting his wishes. Alana is pulled into a surgery with Owen that may change the way she views the hospital's ER.
Alex and Jackson are pitted against each other to become the next "face" of Seattle Grace while they work on a sex reassignment surgery for a trans-gender teen. Then, April brings in an emergency trauma case which requires the help and discretion of many of the doctors. Meanwhile, Callie and Richard visit a recently revitalized hospital to understand what they are all in for.
As the hospital inches closer to finding a buyer, many of the doctors don't like the new changes being made, causing the crash survivors to consider a crazy idea. Meanwhile, April's relationship with Matthew progresses and she asks Jackson for advice.
The crash survivors race against the clock to find a buyer for the hospital before Pegasus closes in. Meanwhile, the interns and other doctors at SGMW plan for what they believe will be their imminent departure while Jackson's mother continues to try to convince him to move to Boston.
With the new Grey Sloan Memorial Hospital up and running smoothly, everyone is happy about the new changes. Meredith worries about the health of her baby while Bailey tries to get the board members to fund her new plan for genome mapping. Meanwhile, Arizona's new prosthetic gives her the confidence to reignite her relationship with Callie. With the help of a patient, Alex pulls some pranks on Jo's new boyfriend and Cristina tries to get involved in groundbreaking cardio research.
When a giant gas tanker explodes on a highway, a couple of parents are admitted to the hospital while Owen looks after their son. Matthew is caught in the explosion and is admitted to the hospital while a single mother fights to find out what mysterious illness is plaguing her son.
A couple of Syrian doctors arrive at Grey Sloan Memorial to learn field techniques for war zones. Then, when a series of patients return with post-op infections, one doctor's work falls under suspicion.
At Jackson's request, the CDC arrives at the hospital to begin an investigation surrounding Bailey's patients. April blames Jackson for her breakup with Matthew and Alex tries to be nice to Jason. Owen continues to get closer to Ethan as his dad's health remains uncertain.
A magician's assistant arrives at the hospital with a severe injury that has all the general surgeons involved, except for Bailey who is ignoring all of the attendings. As Cristina searches for a way to wake his father up, Ethan has a medical emergency of his own. Alex tries to avoid Jo at the hospital and a new cranial-facial specialist flirts with Arizona.
With a major storm rolling in, the hospital is chaotic. When Jason comes into the hospital in critical condition, Alex does everything he can to protect Jo. With Meredith's due date just weeks away, Derek urges her to slow down.
As Seattle is plunged into a major storm, Meredith goes into labour. When the hospital loses power, her doctor and all the others are forced to work in the dark. Cristina must perform surgery in almost complete darkness while Arizona, Alex, and Lauren must ward off terrified parents. Then, just outside the hospital, a school bus full of people crashes and flips over, forcing several doctors to rescue its passengers. Cristina finally confronts Owen on his desire to have kids.
Ben worries that an innocent conversation with Derek could end up causing problems for Bailey; Cristina turns to Shane as tension with Meredith increases; April's upcoming wedding creates an uncomfortable situation for Stephanie and Jackson.
The doctors face the consequences of the events that took place at April's wedding. Meredith feels betrayed when Derek goes back on a promise, Alex is furious after returning to the hospital and hearing the news about his father, and Arizona and Callie decide whether or not to move forward together. Meanwhile, Bailey realizes she was wrong about the motive behind Ben's decision to move back to Seattle.
Couples panic when the hospital announces a nonfraternization policy; Owen and Emma discuss the future; Meredith and Cristina have some girl time; Richard asks the residents for help with a rare cancer case.
Arizona's bad day escalates when she advises a patient on a potential double amputation; Derek breaks a promise; Stephanie and Jo find an abandoned baby; the nonfraternization rule leads to a suspension.
The doctors of Grey Sloan Memorial Hospital succumb to an infection that spreads like wildfire. Cristina deals with a complex case involving siblings and Alex begins to consider his future in the hospital.
Callie and Arizona discuss having another baby, Derek has a hard time juggling work and family, Jackson and April have their first big fight and Christina attends the Harper Avery Award Ceremony. But is she going to win?
The doctors work together to operate on two sisters joined at the head; Cristina travels to Zurich where she deals with a blast from her past; Richard voices his concern over the hospital's allegiance with the Harper Avery Foundation.
While Bailey faces dire consequences for her reckless behavior, Cristina interviews candidates for Dr. Russell's replacement. Alex returns with a motive, disappointment hits Callie and Derek brings forth a shocking proposal to Meredith.
Cristina must head to Zurich soon but she is unprepared to leave behind her life in Seattle. Fear runs amok throughout the hospital as an explosion in a shopping mall results in a mass casualty situation.
Callie and Arizona have to make a choice regarding surrogacy while the board has to decide whether to give Cristina's seat on the board to Alex or Bailey. Amelia overhears the truth about Maggie Pierce.
In this Maggie-centric episode, she continues to try to make a positive impression at the hospital but finds herself in extremely unfortunate situations. Meanwhile, Richard continues to hold onto his secret and the doctors work with a dying woman who is being kept alive by her daughter.
Owen introduces Callie to the Veterans Hospital patients in hopes that she will help them with her robotic limb lab, Jo becomes jealous of Alex and Meredith's friendship, and Maggie continues to confide in Richard. Meanwhile, Alex and Bailey prepare to go in front of the board.
Secrets from Ellis Grey's past come to light when Meredith watches old videos and reads through her mother's journals. Meanwhile, Maggie rocks the hospital with an unexpected announcement; Alex gets new responsibilities and Callie focuses her attention on the Veterans' project.
Callie and Arizona examine their marital problems and what's contributed to them. Meanwhile, Callie devotes herself to the veterans' project; Arizona strives to impress Dr. Herman; and Richard seeks guidance from Bailey.
A woman comes in badly hurt from a car jack and Owen pays some extra attention when she is found to have served in the military. Derek desperately tries to organize a dinner binding together Meredith's complicated family but is fought from every angle. Meanwhile April reacts strongly to the arrival of her mother and Arizona is fighting hard to manage under the pressure from her new "boss".
Arizona has to take care of one of Herman's patients. Everybody finds out Amelia was a drug addict and Derek lets her down. Jo has her first solo surgery. Maggie is invited to Ellis' house and Arizona decides to move in with Alex.
Pierce and Grey disagree with Derek about the best way to approach a patient's case, which lead the couple to a very big argument. Meanwhile Callie feels responsible for one of her veterans when he is pushed too far and a doctor's routine procedure shows devastating results.
April stays positive as tests are run on her baby; Dr. Herman plans a crash course in fetal surgery; Callie and Owen encourage each other to return to the dating scene; Bailey, Meredith and Maggie try to learn more about a patient's tumor.
Maggie gets upset when Meredith dodges her questions about DC; Bailey and Ben become concerned about Ben's brother after he is admitted to the hospital, and Dr. Herman starts to warm up to Arizona. Meanwhile, Richard feels manipulated by Catherine.
The hospital doctors become fascinated with Dr. Herman's case when Amelia gives a lecture detailing the intricacies of the surgery. Arizona and Herman continue to bond over the amount of cases they are trying to complete before the big surgery. Meanwhile, Bailey brings them a case of a pregnant woman who is close to her heart.
A group of children visit the hospital on a field trip and observe two injured cops rushed into the emergency room. Meanwhile, Stephanie develops a crush on one of the chaperones, and Amelia's forced to confront her feelings about Owen.
Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs into action when a man is brought into the hospital after his wife seeks revenge on his cheating ways.
The doctors from Grey Sloan Memorial Hospital spring into action to save the lives of two girls with a powerful story. Meanwhile, Meredith tries to cope with the fact that Amelia is now living with her and Jackson prepares for April's return back to Seattle.
The pressure is on as a determined Bailey tackles her first day as Chief; meanwhile, April's marriage is in jeopardy and she finds herself unable to address her problems; Meredith struggles to juggle all her responsibilities and Amelia works to define her relationship with Owen.
Maggie leaves her dinner party and races to the hospital, so April takes over the cooking duties in an attempt to avoid Jackson. Meanwhile, Arizona is extremely anxious about meeting Callie's new girlfriend, who happens to be a familiar face in Meredith's life.
A high-stakes case is tackled by a team of doctors, and the atmosphere grows tense. Meanwhile, Bailey pressures Ben to evict their roommate; and Arizona enthusiastically reenters the dating scene with a new wingman.
As the rumor mill around the hospital continues to spiral out of control, Grey Sloan Memorial is flooded with injured firefighters from a nearby wildfire. Maggie struggles to keep things with Andrew professional at work; meanwhile, Jo questions Alex's priorities. Also, Alex decides to make a big step in his life.
As the hospital deals with Meredith's trauma, Callie and Maggie perform a risky, experimental surgery on Alex's 15-year-old patient against his professional opinion. Meanwhile, Owen and Nathan are still at odds with each other, and Maggie and Andrew's relationship continues to develop.
Flashbacks reveal the evolution of April and Jackson's relationship, beginning with their initial meeting, and the years-long process of one of Jackson's patients. Also, April finds out something life changing.
Meredith, Jo, Bailey, Callie and Jackson head to a Veterans hospital for an spectacular yet unusual surgery. Meanwhile, a group of snobby cheerleaders come into the ER and Warren makes a risky decision.
Jackson learns about April's pregnancy, while Alex and the team of doctors handles a long triple-organ transplant surgery. Meredith considers dating again, and Andrew insists on not receiving special treatment after he and Maggie go public.
Meredith takes a step forward with Will but quickly regrets it; Maggie senses a disconnection with Andrew; and Amelia reevaluates her relationship with Owen. Meanwhile, Catherine comes into town and really shakes things up with April and Jackson
After a missing child forces the hospital into lockdown, Ben decides to operate on a pregnant mother without the proper surgical equipment. Miranda, as Chief, is faced with the repercussions of the event.
Stephanie's relationship to Kyle becomes complicated. Meredith encourages Amelia and Owen to take a chance and choose to be a real couple. Arizona and Callie are at odds and put their friends in the middle of an uncomfortable situation.
Callie and Arizona are at odds over Sofia's future, and Stephanie questions the status of her relationship with Kyle. Meanwhile, Alex and April work on a pregnant teen that is readmitted to Grey Sloan Memorial.
Meredith and Maggie support Amelia on an important day; Jo reveals that she has been keeping secrets from Alex while Arizona and Callie deal with the impact of their custody arrangement. Meanwhile, Ben leaps into action to help a friend.
When one of Grey Sloan's own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help; Meredith juggles huge secrets that affect her relationships with Alex and Maggie; Richard helps Jo with a big decision; April and Catherine clash over the new baby.
Meredith thinks about her loyalties while Alex deals with the fallout of his actions; Amelia and Owen host a dinner party with surprising guests; Jackson makes a suggestion to help April through her recovery.
A familiar face returns to Grey Sloan throwing many of the doctors for a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex while a tough ER case makes Amelia's bad day even worse.
Richard, Jackson, April and Catherine tackle a grueling trauma case intensified by hospital politics; Amelia finally faces her feelings about Owen; Meredith gets caught between Nathan and Alex over a patient.
The doctors of Grey Sloan encounter a difficult case involving a dangerous patient; Owen receives life-changing news that pushes Amelia to step up to support him; Alex attends a medical conference after making a shocking discovery.
Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire and the doctors are introduced to a few new faces that spice things up around the hospital.
Amelia confronts a difficult situation; Meredith deals with the fallout from her conversation with Nathan; Maggie finds herself at an awkward family dinner; Jackson receives big news; Richard and Bailey search for the stars of tomorrow.
April is in charge of the new surgical innovation contest; the doctors are eager to start their projects; Catherine's old friend has a shocking idea for Catherine and Jackson; Meredith treats a returning patient who inspires her project.
Maggie's relationship with Clive starts to progress; she invites him over for a game night to meet Meredith and Amelia; Meredith and Jo meet with the owner of the patent to the polymer they need for their project, who is a friend of the family.
An agent from U.S. Immigration and Customs Enforcement searches the hospital for an employee; Alex's patient wants to leave the hospital to enjoy her final days, but Alex feels differently; Arizona treats Matthew Taylor's baby.