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Two Harkonnen sisters combat forces that threaten the future of humankind and establish the fabled sect that will become known as the Bene Gesserit.

Paul Atreides unites with the Fremen while on a warpath of revenge against the conspirators who destroyed his family. Facing a choice between the love of his life and the fate of the universe, he endeavors to prevent a terrible future.

Paul Atreides arrives on Arrakis after his father accepts the stewardship of the dangerous planet. However, chaos ensues after a betrayal as forces clash to control melange, a precious resource.