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- Recounts the events leading up to Raquel to be one of the biggest psychopaths in recent times.
- A group of teen friends decides to start a band. Through the episodes we see different situations that test their friendship.
- A Montevideo journalist discovers that the murder of a boy from the slums near the vineyards had political reasons, and was not an isolated incident. Developing a friendship with the victim's older brother, and then the entire family, the journalist tries to get to the bottom of this case. It is not the only case of summary executions of young poor boys in this vineyard, but nevertheless few people really want to challenge the powerful owner of the vineyards.
- Neela's marathon shift begins to affect her, and her demeanor isn't helped when she learns the med student she is mentoring is abandoning her specialty.
- A firefighter is brought in after being injured at a fire that is blamed on a young girl with genetic problems. Abby decides to prove the girl did not cause the fire. A disfigured man saves his anti-social neighbor. An old woman dies unattended at the ER while the staff are waiting for a psychiatrist. Pratt backs up Abby in an administration meeting. Neela's cousin apparently chooses Harold.
- Abby returns to work; Luka applies for a job elsewhere; the reason behind a brash doctor's being at County is revealed.
- The police wheel in a casualty of a drug deal-turned-shoot-out. They also bring in an injured woman who was the shooter, plus a pair of wounded brothers who were shot by the man who was shot dead. A 13-year old girl with sickle cell disease is brought in because of abdominal pains; Neela takes her case while Tracy learns from her. Banfield's pregnancy test is negative, which leads to a discussion with her husband and a visit to a specialist.
- Gates and Julia nurture their newfound romance but are soon interrupted by a troubled phone call from Gates' ward, Sarah.
- A young woman with a failing liver has a difficult reunion with her parents, whom she has not seen in six years. Abby receives a job offer. Brenner isn't nice to Laverne after they sleep together.
- Moretti reassigns Gates back to the ER and treats a couple involved in a car accident. Morris prepares to take his written board exams. Neela is assigned a young genius intern. Kovac plans to extend his stay in Croatia while Abby struggles with single parenthood.
- Abby and a distracted Morris work to save two auxiliary cops brought in with gunshot wounds. Pratt treats a teen wrestler with severe vomiting, but the problem is much more serious. Sam worries over her new beau Litchman. Gates tries to help a young boy in the ICU with a deadly disease. Also, Dubenko visits Neela while she babysits baby Joe.
- In 12 hours, the ER will shut down. As Kovac is under pressure to take care of the patients before the final hours, he makes a pivotal decision about his future. Meanwhile, Sam befriends a photojournalist who returns only this time she's terminally ill; Pratt is concerned when his brother ends up in the ER drunk; Morris confronts Gates when he ignores his orders and angrily sends him home while Gates tries to defend his actions.
- Dr Wexlar is made interim ER chief while staff deals with an industrial accident that leads to a hate crime.
- A girl who was hit by a car while riding a bicycle is treated in the ER. When her boyfriend turns up, it seems it may not have been an accident. While a lottery has made millionaires of several nearby convenience store workers, Dr. Banfield and her husband are at the fertilization clinic hoping for their one in a million chance. And as an older woman is brought in assisted by her on-again, off-again husband, three love stories continue in the ER: Dr. Morris meets policewoman Diaz again, Sam discovers that Tony has been seeing Daria, and Neela plays it cool with the returning Dr. Brenner.
- Abby deals with her upcoming reunion with Luka in Croatia, a heart transplant patient is admitted when her body rejects the new heart, and a new doctor ruffles feathers.
- Abby and Luka desperately try to keep a young woman alive who was brought into the ER with stab wounds to the neck. As her condition worsens, Clemente steps in and tries a risky procedure on her to save her life. Meanwhile, Neela pulls an all-nighter preparing to speak at a surgeons' convention; Ray treats a man who claims he has swallowed a bottle of pills; and Sam decides to take a part-time job with Richard to help with childcare expenses.
- A blizzard strands a family in the snow and Abby and Pratt quickly try to save the family. A gang shooting challenges Morris and Pratt. Meanwhile, Kovac and Abby begin making wedding plans, but their engagement might not be very secret; Gates struggles with the reappearance of his father and the possibility of losing Sarah; and Neela becomes jealous when Dubenko brings in a new surgical intern.
- The ER reopens with new changes. However, the ER is not the only thing that's changed; Kovac and Abby adjust to being newlyweds; Morris and Hope enjoy themselves at the honeymoon suite; Pratt attempts a change for a woman; Neela worries when Ray goes missing; Meanwhile, there's a new doctor in the ER and he means business; and another change may come when Kovac receives a phone call.
- Kovac and Gates deal with a hopeless father whose son succumbs to heart failure; Pratt tries to resolve the tension between him and his brother; an Armenian man tries to be a good samaritan but ends up crashing near the ER; Abby sneaks in baby Joe when she worries his sickness may be worse than it seems; Also, Sam injures the instructor of a self-defense seminar.
- When two teens are in a car accident, Abby and Morris struggle to figure out what is wrong with the unconscious girl. Meanwhile, Neela gets a visit from her in-laws and discovers some troubling news. Kovac tells Abby that he plans to go to Africa and help Carter, but when he realizes Abby is not crazy about the idea, he decides to send someone else in his place. Sam starts her new job with Elliot and quickly starts to love the the perks.
- The Last One Before Christmas Break. The one in which Frank and Drs. Sanchez and Wade accidentally get brownies with cannabis in it. The one with the Christmas party. Archie's cousin brings Archie's deceased father's storage container to the ER bay. An injured pregnant Latino woman is brought in. There is something wrong with her baby?. Plus, the Immigration Office wants to deport her.
- Weaver contemplates hip replacement surgery after she finds it hard to do her labor-intensive job. Meanwhile, Kovac tries to ease Abby's fears about raising a child together. Neela decides to attend a support group for military spouses but when she offers her opinions on the war, the meeting turns into a debate. And after Sam treats a fainting victim, she finds herself with an intriguing job offer.
- Moretti brings in new attending Skye Wexler to help with the patient load. Morris and Pratt cram for the medical board exam. Gates treats a returning patient from the ICU whose condition has worsen. Sam tends to a teenage girl who is feeling neglected by the staff. Neela's intern, Harold, seeks her advice on a personal matter. Abby struggles with her relapse.
- A single mother is hurt in a car accident, and must find someone to take care of her daughter. Gates treats a 78-year-old man who refuses surgery that would save his life. Meanwhile Morris's afternoon date with Claudia is not what he expected.
- When a thirteen-year-old gymnast is brought into the hospital after having supposedly fallen off a wall, Dr. Banfield and Dr. Gates must sort out whether abuse is involved.
- As a snowstorm hits Chicago, Sam's son Alex crashes a car and ends up in critical condition in the ER. Neela gives a deposition in the malpractice suit against her. Dr. Morris and Dr. Banfield are both at a medical conference in Omaha, and when the snow cancels all flights out they share a memorable and surprising evening.
- Kovac anxiously awaits the verdict between himself and Curtis Ames but fears the worst. Meanwhile, Neela disobeys her chief's orders and also questions her feelings for Gates, and Weaver unwittingly steals the spotlight from Morris in his big television debut.
- Kovac and Gates find themselves with a moral dilemma when a woman comes into the ER with acute liver failure; Neela finds herself questioning what is right when Manish decides to give up a kidney to a complete stranger. Meanwhile, Ray fights to get to the bottom of a cheerleader's accidental fall; Abby gets a prediction for her future; and Alex's troubles continue to intrude on Sam's work life.
- Patients include a pregnant teacher whose student/lover was critically injured while driving; a man who is hiding a gunshot wound and a brilliant young boy who knows he is dying, but hides it from his mother. Dr. Moretti continues to remake the ER to his liking, Neela is recovering, Luka's absence is reinforced (back in Croatia and not coming back) and Sam may be starting a new relationship with a police officer.
- The ER is on guard as Gates gathers the new interns to treat a terrorist, but it's the new doctor and her tough disposition that has everyone on the defensive.
- Morris is named the new chief resident, which makes nobody really happy, except Morris. Meanwhile Luka and Sam are having communication problems, Carter gets a promotion Susan really wanted and Ray finds out a 14-year old who always comes in for free drugs has been raped.
- Abby and Kovac discover both the joys and difficulties of raising a newborn; Morris is wrongfully accused of being a child molester; Pratt has his trial-by-fire when he has to handle the ER alone, juggling multiple traumas, teaching duties and a troublesome intern. Neela continues to be the target of her difficult supervisor, and Sam discovers her sons latest extra-curricular activity.
- A wounded police officer's teenage son must make a life or death decision. Abby tries to convince a girl needing appendicitis surgery's parents not to transfer her and do the operation at County, but her father wants her transferred to another hospital due to his own trauma with surgery complications from years before.
- While examining a young boy, Pratt finds a suspicious gash across his chest and calls Wendall for a consult. Kovac and Pratt examine a man who was shot when he confronted his boss with a gun. Jake tries to convince Abby to date him despite his being her student.
- Gallant impulsively asks Neela to marry him that exact day; she says I do but soon gets cold feet. Morris stands up to Weaver on a patient's course of treatment. Luka, Sam and Clemente treat a boy who contracted HIV from his mother. Also, Abby and Luka redefine their relationship and Luka is named the new Chief of Emergency Medicine.
- A woman on a hunger strike refuses treatment until the INS give her son another deportation hearing. Abby searches for proof when she suspects a patient is the victim of elder abuse.
- A rape victim, barely able to speak, does all she can to help police find her attacker.
- Morning shift begins. The night shift treated 142 patients - a new record. Dr. Morris is confident that by the end of the day the ER can set a new record of 300 patients. Frank reminds him that there has never been more than 250 patients in a day. Dr. Morris bets $300 that they can reach 300 by the end of the shift. Frank, Dr. Gates and Dr. Pratt each bet $100 against him. But will the game be fair? Also, when chaplain Dupree arrives announcing that she's doing a round of the hospital, holding blessing ceremonies and memorials, the guys are against it, except for Dr. Gates, which makes the others suspicious. Frank goes straight to the point. Then there is the accident involving a camel.
- Abby and Sam try to treat an aspiring comedian with mysterious symptoms; Pratt must defend his actions in front of the medical board; Neela scrubs in on a kidney donor transplant; and Morris, as the lone attending, must run a busy ER. Also, Kovac gets a surprising proposal from Abby.
- A young couple is choppered to County after a car accident, and one of them has a gun. A boy who wants to be a clown is injured in a unicycle mishap, but his father considers him a mathlete and wants him to go to MIT. Pratt visits Bettina in the hospital, but she tells him off.
- An unexpected visitor puts Clemente in the middle of a domestic dispute. Meanwhile, Luka and Abby await test results on their unborn child; Neela struggles with her surgical elective and Pratt ends up with an unexpected suitor when he participates in a charity bachelor auction.
- The rainy night brings in diverse patients, including a mother involved in a car accident with her baby, a man with a satisfaction facilitator, and a comatose patient who suddenly wakes up. Also, Sam stands up to Eve and her strict ways and Jerry gets struck by lightning.
- Weaver cares for a Katrina survivor who's reluctant to have surgery on her foot; budget cuts force Luka to make a difficult personnel decision. Also, Gates' home life intrudes on the ER; and Pratt and Hope are shaken after a patient in their care dies needlessly.
- Carter misses his pregnant girlfriend who has returned to Africa. A family of four is rushed to the emergency room after suffering carbon monoxide poisoning from their faulty furnace--forcing the claustrophobic Neela to accompany a newborn baby into an extremely uncomfortable hyperbaric chamber.