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- A blizzard strands a family in the snow and Abby and Pratt quickly try to save the family. A gang shooting challenges Morris and Pratt. Meanwhile, Kovac and Abby begin making wedding plans, but their engagement might not be very secret; Gates struggles with the reappearance of his father and the possibility of losing Sarah; and Neela becomes jealous when Dubenko brings in a new surgical intern.
- The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- Carter misses his pregnant girlfriend who has returned to Africa. A family of four is rushed to the emergency room after suffering carbon monoxide poisoning from their faulty furnace--forcing the claustrophobic Neela to accompany a newborn baby into an extremely uncomfortable hyperbaric chamber.
- Benton takes a day off to help Carla. Carter finds out Edson falsified a chart.
- Kayson, a married man, tries to start a romance with Susan by asking her to dinner. Deb unknowingly eats LSD-laced chocolates. Carol takes an interest in a Russian girl abandoned in the ER.
- Benton performs dangerous surgery on a bomb-carrying man who was shot at a factory. Dr. Ross receives some good news that Dr. Weaver doesn't embrace, but she has no recourse. Rachel encourages Dr. Greene to help a horse that is in pain. Jeanie Boulet returns from her vacation.
- Lucy finally admits to Carter that she doesn't know how to start an IV. Weaver interviews for the job as the ER Chief. Benton keeps his son's disease a secret. Jeanie intervenes when she finds out a liver transplant candidate is drinking again, and later asks Doug if she can be assigned to work for his pedes project in the ER. Corday gets stuck as the intern of dismissive and insulting Dr. Dale Edson.
- While victims of a gang shootout are being brought in, Carter is late and a new group of third year medical students arrives.
- Pratt struggles to get a straight story when two abused boys come into the ER with their father. Two U.S. Army officers enter the ER.
- Curtis Ames, a carpenter who suffered a stroke under Kovac's care, sues him for malpractice. Kovac and Ames square off in court as each man's recollections of Ames' treatment are recounted via testimony and flashbacks. Meanwhile, Abby returns to work and must adjust to the dramatic changes in her life, and Pratt's early morning trip to the barbershop results in a new awareness of community need. Also, Abby and Pratt try an unconventional method for treating a heart patient and Neela tries a risky procedure which doesn't sit well with her chief.
- Kovac anxiously awaits the verdict between himself and Curtis Ames but fears the worst. Meanwhile, Neela disobeys her chief's orders and also questions her feelings for Gates, and Weaver unwittingly steals the spotlight from Morris in his big television debut.
- A belligerent young man who claims to have the flu turns out to be more than he seems, and presents a challenge to Morris and Sam when he refuses treatment. Abby's chance encounter with Curtis Ames leaves Kovac uneasy. Meanwhile, Pratt discovers a local church's risky drug exchange program, Neela and Gates square off, and Weaver gets an interesting offer.
- A mysterious illness leaves little hope when a group of homeless kids enter the ER and one of them believes that Neela is a guardian angel in blue; Abby and Kovac clash over a possible case of domestic abuse; Pratt makes a shocking discovery about his brother, and Weaver is unexpectedly called into action when her television appearance becomes a real emergency.
- Kovac reacts negatively when he sees Abby giving extra attention to a patient; Ray and Gates clash over a patient, pinning Neela in the middle; and Ben takes things to the next level with Sam. Meanwhile, Pratt is under investigation and Weaver says a final goodbye to the ER.
- Weaver cares for a Katrina survivor who's reluctant to have surgery on her foot; budget cuts force Luka to make a difficult personnel decision. Also, Gates' home life intrudes on the ER; and Pratt and Hope are shaken after a patient in their care dies needlessly.
- Abby and Sam try to treat an aspiring comedian with mysterious symptoms; Pratt must defend his actions in front of the medical board; Neela scrubs in on a kidney donor transplant; and Morris, as the lone attending, must run a busy ER. Also, Kovac gets a surprising proposal from Abby.
- Kovac finds himself in a tense confrontation with Curtis Ames, and Abby must act to protect her family. Meanwhile, Neela and Gates rush to get Meg to the hospital while Sam's new home is soon under threat from fire.
- Kovac and Gates find themselves with a moral dilemma when a woman comes into the ER with acute liver failure; Neela finds herself questioning what is right when Manish decides to give up a kidney to a complete stranger. Meanwhile, Ray fights to get to the bottom of a cheerleader's accidental fall; Abby gets a prediction for her future; and Alex's troubles continue to intrude on Sam's work life.
- It's Sam's birthday, but she finds it hard to be away from her son Alex. Meanwhile, Sam meets a photographer taking pictures of a terminal patient and she gives Sam a new perspective on life. Dubenko's new surgical intern unsettles Neela during a trauma; Gates is shadowed by a new and nerdy intern and later must tell Sarah the truth that he may be her biological father. Also, Morris and Hope annoy Kovac and Abby when they try to help with their wedding preparations.
- Kovac and Gates deal with a hopeless father whose son succumbs to heart failure; Pratt tries to resolve the tension between him and his brother; an Armenian man tries to be a good samaritan but ends up crashing near the ER; Abby sneaks in baby Joe when she worries his sickness may be worse than it seems; Also, Sam injures the instructor of a self-defense seminar.
- The ER reopens with new changes. However, the ER is not the only thing that's changed; Kovac and Abby adjust to being newlyweds; Morris and Hope enjoy themselves at the honeymoon suite; Pratt attempts a change for a woman; Neela worries when Ray goes missing; Meanwhile, there's a new doctor in the ER and he means business; and another change may come when Kovac receives a phone call.
- Patients include a pregnant teacher whose student/lover was critically injured while driving; a man who is hiding a gunshot wound and a brilliant young boy who knows he is dying, but hides it from his mother. Dr. Moretti continues to remake the ER to his liking, Neela is recovering, Luka's absence is reinforced (back in Croatia and not coming back) and Sam may be starting a new relationship with a police officer.
- Abby and a distracted Morris work to save two auxiliary cops brought in with gunshot wounds. Pratt treats a teen wrestler with severe vomiting, but the problem is much more serious. Sam worries over her new beau Litchman. Gates tries to help a young boy in the ICU with a deadly disease. Also, Dubenko visits Neela while she babysits baby Joe.
- The city suffers power outages during an unseasonably hot spell. Nursing-home patients are brought into the ER suffering from hyperthermia. Abby and Pratt disagree on the diagnosis of a fussy baby. Abby falls back to old habits and quickly spirals down to rock bottom on a night she'll forever regret.
- Moretti brings in new attending Skye Wexler to help with the patient load. Morris and Pratt cram for the medical board exam. Gates treats a returning patient from the ICU whose condition has worsen. Sam tends to a teenage girl who is feeling neglected by the staff. Neela's intern, Harold, seeks her advice on a personal matter. Abby struggles with her relapse.
- Gates and Julia nurture their newfound romance but are soon interrupted by a troubled phone call from Gates' ward, Sarah.
- Dr Wexlar is made interim ER chief while staff deals with an industrial accident that leads to a hate crime.
- Dr. Pratt applies for the job of ER Chief and gets turned down. This causes him to give 2 weeks notice. A female soldier, home 2 weeks from Iraq, is 2 months pregnant and her husband demands an explanation. Neela's cousin has arrived from London for an extended visit and gets pursued by both Dr. Morris and Harold Zelinsky. After 9 years absence, a fall in gym by her son brings Jeanie Boulet back to the ER. Not only is she troubled because of her son, but the disorientation of knowing virtually no one on the current staff does not help.
- A firefighter is brought in after being injured at a fire that is blamed on a young girl with genetic problems. Abby decides to prove the girl did not cause the fire. A disfigured man saves his anti-social neighbor. An old woman dies unattended at the ER while the staff are waiting for a psychiatrist. Pratt backs up Abby in an administration meeting. Neela's cousin apparently chooses Harold.
- Abby deals with her upcoming reunion with Luka in Croatia, a heart transplant patient is admitted when her body rejects the new heart, and a new doctor ruffles feathers.
- A young couple is choppered to County after a car accident, and one of them has a gun. A boy who wants to be a clown is injured in a unicycle mishap, but his father considers him a mathlete and wants him to go to MIT. Pratt visits Bettina in the hospital, but she tells him off.
- The ER staff deals with the aftermath of the explosion including a severely injured doctor.
- The police wheel in a casualty of a drug deal-turned-shoot-out. They also bring in an injured woman who was the shooter, plus a pair of wounded brothers who were shot by the man who was shot dead. A 13-year old girl with sickle cell disease is brought in because of abdominal pains; Neela takes her case while Tracy learns from her. Banfield's pregnancy test is negative, which leads to a discussion with her husband and a visit to a specialist.
- Neela experiences alternate versions of the same day.
- A single mother is hurt in a car accident, and must find someone to take care of her daughter. Gates treats a 78-year-old man who refuses surgery that would save his life. Meanwhile Morris's afternoon date with Claudia is not what he expected.
- Dr. Carter returns to Chicago and talks Dr. Banfield into allowing him to pick up a number of shifts (without pay). Other happenings include Banfield's dogged pursuit of motherhood, Neela's intensifying personal relationship, and Archie's involvement with a patient who was probably beaten while in police custody - with his new girlfriend the detective standing by.
- Carter's illness overtakes him during a critical procedure in a trauma room as a documentary film crew spends the day interviewing the health care givers.
- A girl drops off a sick baby at the ER and then leaves; Carter may get a kidney transplant; Gates and Daria care for an elderly woman with multiple sclerosis; Neela and Sam are in Seattle to transport a heart for Joanie Moore, while Doug and Carol are concerned that the donor's grandmother might not consent.
- The ER is on guard as Gates gathers the new interns to treat a terrorist, but it's the new doctor and her tough disposition that has everyone on the defensive.
- On Neela's last day at County, she has doubts as to whether she is making the right decision.
- The ER doctors and nurses help out at Camp Del Corazon, a camp for kids who have had open-heart surgery, working alongside the camp counselor.
- When a gunshot wound victim arrives, the new chief and Abby butt heads on how to treat the patient. Abby comes to Sam's defense when she goes before a nurses disciplinary board.
- When a thirteen-year-old gymnast is brought into the hospital after having supposedly fallen off a wall, Dr. Banfield and Dr. Gates must sort out whether abuse is involved.
- Both Morris and Neela have authority issues with Dr. Banfield and Gates upsets Sam.
- A woman who broke her leg while trying to escape a house fire is brought in with her husband. The husband, Mr. Lotery did not let the paramedics to check him over. Then his brother-in-law arrives, saying that he predicted that something like the house fire would happen - it was actually an arson. Mr. Lotery's brother-in-law becomes aggressive and accuses him of being a pervert, specifically a pedophile. Mr. Lotery denies the accusations. He was sued but found not guilty. When Mr. Lotery is waiting for his wife who's in line for X-ray, he has the chance to calm down a young girl who is afraid of needles. When his brother-in-law sees this, he brutally assaults him, while Dr. Brenner calmly watches nearby... Meanwhile, Neela gets sued for malpractice.
- As a snowstorm hits Chicago, Sam's son Alex crashes a car and ends up in critical condition in the ER. Neela gives a deposition in the malpractice suit against her. Dr. Morris and Dr. Banfield are both at a medical conference in Omaha, and when the snow cancels all flights out they share a memorable and surprising evening.
- At the hospital daycare, one of the child-care workers suggests to Peter Benton that he may want to have baby Reece's hearing checked. Doug Ross dodges a bullet by admitting upfront his error in detoxifying a baby without permission. Having been acting Chief for over 6 months, Kerry Weaver puts her name forward to replace David Morgenstern as Chief of Emergency Medicine only to be told she will have to compete for the job. The doctors treat a couple of Elvis impersonators who sky dive into Lake Michigan. When drugs go missing from the ER, John Carter suspects Anna Del Amico's ex-boyfriend.