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The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.

Two storm chasers on the brink of divorce must work together to create an advanced weather alert system by putting themselves in the cross-hairs of extremely violent tornadoes.

A spaceship is discovered under three hundred years' worth of coral growth at the bottom of the ocean.

A computer specialist is sued for sexual harassment by a former lover turned boss who initiated the act forcefully, which threatens both his career and his personal life.

The pilot for the popular TV series is set during 24 frantic hours in the lives of a group of doctors, nurses, and staff members of a busy emergency room at a Chicago hospital. They deal with the seemingly endless casualties that stumble into their place of employment. The central characters are the chief resident and family man Dr. Mark Greene, who is considering a job in private practice due to pressure from his demanding law student wife Jennifer; outgoing Dr. Doug Ross, who deals with cases in his own personal way; straight-arrow Dr. Susan Lewis, trying to get by another long 36-hour shift; inexperienced third-year med student John Carter; cocky surgical resident Dr. Peter Benton; and troubled chief nurse Carol Hathaway.

Susan Lewis' boyfriend Div Cvetic, a psychiatric resident at County General, seems to be under a great deal of stress regularly lashing out at everyone. Doug Ross takes over for Mark Greene who takes a day off to be with his wife. He has a hard time keeping up with all the paperwork. John Carter is increasingly frustrated with Peter Benton who never seems to invite him to participate in surgeries. Benton learns the result of the fellowship he applied for and his mother shows up in the ER with a sprained ankle. Carol Hathaway treats a patient who was raped. A new ER aide, Bob, start work.

Dr. David Morgenstern returns after a six-month absence recovering from his heart attack. His new outlook on life however has Kerry Weaver questioning his abilities. Elizabeth Corday decides to start a study on the use of artificial blood in the ER, but the only problem is that she fails to discuss it first with Rocket Romano. Doug Ross decides to apply for an ER attending position. Scott Anspaugh suffers a major relapse. Anna Del Amico is confronted by an irate husband who wants his ill wife to terminate her pregnancy. At the free clinic, Carol Hathaway has to deal with the case of an underage high school student who is sleeping with her 40-year-old teacher. Peter Benton hits a pedestrian with a car but Carter helps him out with an important piece of information.

Abby comes close to breaking down trying to deal with her mother. Dr. Pratt goes for his required paramedic ride-along. Dr. Weaver confronts the man who stole her purse. Dr. Lewis has a teen admirer.

At the hospital daycare, one of the child-care workers suggests to Peter Benton that he may want to have baby Reece's hearing checked. Doug Ross dodges a bullet by admitting upfront his error in detoxifying a baby without permission. Having been acting Chief for over 6 months, Kerry Weaver puts her name forward to replace David Morgenstern as Chief of Emergency Medicine only to be told she will have to compete for the job. The doctors treat a couple of Elvis impersonators who sky dive into Lake Michigan. When drugs go missing from the ER, John Carter suspects Anna Del Amico's ex-boyfriend.

On a busy Halloween night, Carter and Abby are the only staffers in costume when victims of an apartment building fire pack the ER. Corday takes on a new med student for a surgical rotation - Paul Nathan, who suffers from Parkinson's disease and decided to pursue medicine after being diagnosed. Despite a difficult first day, both professionally and medically, Nathan makes a difficult diagnosis. Romano's rehab lags behind his expectations, and he begins to think his role in surgery is no longer an option. In a moment of personal weakness, he tries to express his feelings for Corday. Weaver continues to display erratic behavior, raising staff suspicions about her menopause. Luka's burgeoning sex addiction worsens, as an affair with Chuny is revealed, and tensions rise when he treats a patient with a perpetual erection.

Dr. Pratt brings a gun into the ER; Dr. Weaver tries to conceal her pregnancy; a woman plots against her dying husband; Dr. Chen treats math students who overdosed on an unknown stimulant.

Mark has to deal with the fact he can't see Rachel during the holidays and takes care of a Holocaust survivor whose grandchild is missing.

An injured and condemned murderer wants to die in the ER rather than await execution; Abby advises a neighbor to seek shelter from her abusive husband.

Dr. Weaver is in a difficult situation when an alderman tests positive for syphilis. Dr. Carter is impressed when he meets a man who runs an inner city clinic.

Mark has to work for the fourth night in a row while a lot of the staff are absent and the number of patients is towering.

Greene confronts Corday when she orders Rachel out of their home; Abby tries to protect a battered neighbor who refuses to press charges against her husband.

The police question Drs. Pratt and Gallant about a rampage at the diner across from the ER. Dr. Lewis befriends her teen admirer, a cancer patient.

As the new director of diversity, Benton studies medical school applications and discovers that his own academic record did not qualify him--he was admitted because of affirmative action. Weaver feels uncomfortable amongst Legaspi's lesbian friends. Carter treats an unvaccinated child who contracted measles.

Carter greets the returning Kem, but their meeting with his father, Jack, gets tense after Carter announces plans for his grandmother's estate.

Two boys brought in after a fight at school leads Cleo to discover that one of them has a number of bruises and infected wounds. Hathaway's obstetrics nurse, Abby Lockhart, joins the ER as a third year medical student on an ER rotation.

Pratt and Weaver try to create a Christmas miracle when they work to save a girl wounded from gunfire. Eve gets into trouble after punching a disruptive patient. Also, Abby has a special gift for Luka.

Carter and Lucy are discovered and the staff struggles to save them and go on with normal patient care.

A soccer mom finds herself completely aware of everything going on around her, but is unable to move or speak after suffering a stroke.

While a film crew is filming in the ER, it's Elizabeth Corday's first day.

Doug treats dying Chia-Chia. Mark however feels he's not doing the right thing for Chia-Chia.