Enredo

John Wick uncovers a path to defeating The High Table. But before he can earn his freedom, Wick must face off against a new enemy with powerful alliances across the globe and forces that turn old friends into foes.

Condemned by the tyrannical High Table to be on the run for the rest of his life, deadly assassin maestro De Volta ao Jogo (2014) embarks on a Sisyphean mission of suicidal fury to decide his fate after the merciless carnage in John Wick 3: Parabellum (2019). At last, John's violent journey, fuelled by vengeance and grief, ultimately leads him to a fateful confrontation with his former employers, the crime masters that forced him into exile. And as the blood-stained vendetta to destroy those who pull the strings continues, old companions face the brutal consequences of friendship, and all-powerful, well-connected adversaries emerge to bring Wick's head on a platter. But talk is cheap--now guns have the final say. Baba Yaga, the grim messiah of death, must make every bullet count in this bloody, once-and-for-all struggle for freedom.—Nick Riganas

In New York City, John Wick prepares to exact vengeance against the High Table while hiding underground with the Bowery King. He travels to Morocco and kills the Elder, the "one who sits above the Table". In response, High Table member Marquis Vincent Bisset Dee Gramont summons New York Continental Hotel manager Winston and his concierge Charon, where he explains that the High Table has given him unlimited resources to kill John and chastises Winston for previously failing to do so. As punishment, the Marquis strips Winston of his managerial duties declares him "excommunicated," destroys the New York Continental, and executes Charon. The Marquis then enlists Caine - a blind, retired High Table assassin - to kill his old friend, John, threatening to murder Caine's daughter.

John takes refuge at the Osaka Continental, run by his friend Shimazu Koji. The Marquis' second-in-command Chidi, backed by High Table assassins and Caine, arrives to investigate the hotel. Koji's daughter Akira, the hotel's concierge, evacuates the hotel just before the High Table "deconsecrates" it, igniting a melee. John fights through waves of armored assassins, leading to a showdown against Caine. A bounty hunter named Mr. Nobody interrupts their fight and allows John to escape after determining the current bounty for killing John to be insufficient. A wounded Koji repeatedly attacks Caine on John's behalf until Caine reluctantly kills Koji but spares Akira willingly, giving her a chance to one day exact her revenge over her father's death.

John returns to New York and meets with a vengeful Winston at Charon's graveside. Winston suggests that John invoke an old High Table tradition to challenge the Marquis to a duel. Winning would free John of all obligations to the High Table, but he can only request a duel on behalf of a crime family. John travels to the Berlin headquarters of the Ruska Roma crime syndicate, with whom he had severed ties, to request readmission. His adoptive sister Katia stipulates that for readmission, John must kill Killa Harkan, a High Table member who was paid by the Marquis to murder her father. Killa sets up an ambush at his nightclub, but with the aid of Caine and Mr. Nobody, John manages to kill him and regain his status. Winston relays John's challenge to the Marquis, acting as John's "second" and requests that should John win, his excommunicated be revoked and he is reinstated as manager of the rebuilt New York Continental, fully funded by the High Table; should John lose, however, Winston would also die as the challenger's "second".

In Paris, John and the Marquis decide on the duel's parameters - dueling pistols at sunrise the following day at Sacrè-Coeur - in a meeting moderated by the Harbinger, the Table's emissary. The Marquis nominates a reluctant Caine to take his place, while the Harbinger warns that both John and Winston will be executed should either fail to appear on time. The Bowery King arrives in Paris to give John a pistol and a new ballistic suit. The Marquis intends to prevent John from arriving at the duel in time by placing a $26 million bounty on him. John fights off hordes of assassins on his way to Sacré-coyer, including Mr. Nobody, who negotiates a bounty increase to $40 million. During their confrontation, John prevents Chidi from killing Mr. Nobody's dog, causing Mr. Nobody to abandon his pursuit of John.

After Caine and Mr. Nobody assist John in fighting off several assassins - including Chidi, whom Mr. Nobody kills - on the Rue Foyatier, they reach the summit just in time for the duel. John and Caine wound each other through two rounds of dueling, and the third round comes to a halt when Caine severely wounds John. Demanding the right to administer the coup Dee grace, the Marquis eagerly swaps places with Caine. Winston chides the Marquis for his arrogance, revealing that John had not fired his third bullet. John then promptly executes the Marquis with a head-shot, ending the duel. The Harbinger grants John and Caine (as well as his daughter) their freedom from the High Table and reinstates Winston as Hotel Manager of the New York Continental, which will be rebuilt with the High Table's funds. John reflects upon his life and marriage before collapsing from his injuries. Sometime later, back in New York, Winston and the Bowery King bid farewell to John at a gravestone with his name, located next to one with his wife's (Helen) name.

In a post-credits scene, Caine returns to Paris to reunite with his daughter but is approached by a vengeful, knife-wielding Akira.