Based on Ken Baker's 2001 memoir "Man Made," the story follows the E! news correspondent's experience of going through puberty for the first time at age thirty after having a pituitary tumor removed.
The benign tumor rested against his pituitary gland and delayed his puberty and normal development. Though the tumor's removal restored him to hormonally normal masculinity, it resulted in him having to experience all the effects of puberty over an extremely condensed three-week period.
Johnny Simmons portrays the lead who works as a sex therapist in an office headed by Lynch's character. Snow portrays the girl next door, while J.K. Simmons and Bello play his suffocating parents.