But in the last decade, Ryan has all but disappeared from the screen, doing only small, supporting roles here and there. Why did one of the most sought-after actresses in Hollywood disappear?
According to the latest issue of People, it's not because Ryan wasn't getting offers. Rather, she's chosen to focus on her family -- 8-year-old daughter Daisy and rocker boyfriend John Mellencamp. Ryan, now 51, literally disappeared from Hollywood by moving to New York.
"Los Angeles is just about movies. New York is about so much more than that, and so is Meg," said writer Delia Ephron (sister to Nora Ephron, who wrote many of Ryan's movies