The Avatar actress is in line to play the female lead in Marvel Studios' upcoming film, according to The Hollywood Reporter.
She is to play Gamora, a green-skinned humanoid who is the last of a species exterminated by the Badoon race.
Saldana would be starring alongside Chris Pratt, who is playing Star-Lord, and Dave Bautista, who is portraying Drax the Destroyer.
James Gunn will direct the movie, which is set for an August 2014 release date.
Saldana is also due to reprise her roles of Uhura in Star Trek Into Darkness this summer, and as Neytiri for James Cameron's Avatar sequel.
Watch a trailer for Star Trek Into Darkness below: