In the show, she becomes a patient of Charlie Sheen's therapist character and begins a romantic relationship with him, reports femalefirst.co.uk.
The episode will be aired in April.
Sheen, 47, and Lohan have been close since they worked together in "Scary Movie 5".
"They offered me a decent amount of cash to do 'Scary Five' as a cameo. Then they said they are going to hire Lindsay. I thought fabulous," said Sheen who gave Lohan $100,000 to clear her debts.
He believes Lohan, 26, is smart.