At the end of his acceptance speech, Apatow remarked, "Jerry Lewis once said that he didn't think women were funny, so I'd just like to say, with all respect, 'F*ck you!'"
While I’m not sure if bashing an 85-year-old onstage at the Critics’ Choice Awards is the most appropriate venue for such remarks -- I can’t say I disagree with the sentiment. In fact, I wholeheartedly agree with it.
Here’s some backstory on Lewis’ sexist statement: During a Q&A session at the U.S. Comedy Arts Festival in Aspen in 1998, the original Nutty Professor told the audience, "I don't like any women comedians" and "A woman doing comedy doesn't offend me but sets me back a bit.