As Dirty Sexy Money begins, idealistic lawyer Nick George (Peter Krause) finds himself taking over his late father's single client, the rich and dysfunctional Darling family. Patriarch Tripp Darling (Donald Sutherland) is incredibly influential but needs help managing the fragile relationships with his wife Letitia (Jill Clayburgh) and their five grown children; politician Patrick (William Baldwin), promiscuous Karen (Natalie Zea), corrupt clergyman Brian (Glenn Fitzgerald), and immature, party-loving twins Jeremy (Seth Gabel) and Juliet (Samaire Armstrong).
Tripp also needs Nick's help in fending off enemies like billionaire Simon Elder (Blair Underwood). Thankfully, Nick has the support of his wife Lisa (Zoe McLellan) and their young daughter. Other characters are played by Lucy Liu, Will Shadley, Laura Margolis, Bellamy Young, Candis Cayne, Shawn Michael Patrick,