- She only spoke Spanish before moving to the USA. When she arrived in Los Angeles, she was so determined to audition for parts that she pushed herself to learn English, which she managed to do within two years. Her first-ever English-speaking part was in Knock Knock (2015), and it all went from there.
- Was born in Cuba and moved to Spain when she was 19.
- She has central heterochromia. While both of her eyes are green, they have a brown center. In addition, her irises have small dark-brown spots.
- She auditioned for the role of Selina Kyle/Catwoman in The Batman (2022).
- She is the second Latina actress to play a Bond girl, following Talisa Soto in Licence to Kill (1989).
- As of 2023, she has co-starred with Daniel Craig in two movies: Knives Out (2019) and No Time to Die (2021).
- Appeared in preview trailers for Yesterday (2019) but her role was cut from the final edit of the film, leading some fans to consider suing the producers and distributors for false advertising.
- While hosting Saturday Night Live (1975), she reveled that she learned english by watching Friends (1994) and also calls Chandler Bing the 'best' tutor, her Hands of Stone (2016) co-star Robert De Niro visited her father at work and announced that she's becoming an American Citizen in 3 weeks.
- Nominated for an Academy Award for Best Actress for her portrayal of Marilyn Monroe in Blonde (2022). Competed against Michelle Williams, who, also in portraying Monroe, had previously been nominated as Best Actress in a Leading Role for My Week with Marilyn (2011).
- Distant relative of Danny Pino's maternal grandfather Pedro Gonzalo de Armas.
- Ex-daughter-in-law of Dr. Bonaventura Clotet.
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