Holloway disappeared from Aruba during a high school graduation trip. Her body has never been found.
The key suspect is Joran van der Sloot, a Dutch national. He was arrested several times in the case but never charged after giving different stories about her disappearance.
Van der Sloot has since been arrested in connection with the death of business student Stephany Flores Ramírez, 21, in a Lima, Peru hotel room. Police said in June that Van der Sloot had confessed to the girl's killing.
The English-language film is about an undercover journalist who breaks into Van der Sloot's home on Aruba to force a breakthrough in the Holloway case,