Chris Pirillo was born in Des Moines, Iowa, to Joe and Judy Pirillo. Chris graduated from the University of Northern Iowa and was a middle school teacher in Texas for a short time. From 2001 to 2003, he hosted the TV series Call for Help (1998). Pirillo hosted the annual Gnomedex technology conference from 2001 to 2010. He runs several online communities, including LockerGnome, which was registered in 1996. He also regularly posts videos on YouTube, and his channel has over 300,000 subscribers. Pirillo lives in Issaquah, Washington, with his wife, Diana.