- Recorded "Every Breath You Take" with Sting, and "Chances Are" with Vonda Shepard, both for the "Ally McBeal - Songs of the Heart" soundtrack.
- (October 2001) Release of the music video for the single, "I Want Love," by Elton John, from John's album, "Songs From the West Coast," released October 1, 2001. The video was directed by Matthew Bice, and featured Robert Downey Jr., the only person to physically appear in the video, lip-syncing the entire song, in what appears to be a continuous take of one long shot where the camera follows Downey from room to room of a large empty mansion (actually the Greystone, or Doheny, Mansion in Beverly Hills, California).
- (2002) Magazine advertisement for Skechers Collection footwear.
- (2004) Promotion and limited personal appearance tour for The Route V50 (2004) film online, a twelve minute featurette he made, in 2003, for Volvo, then a division of Ford Motor Company's Premier Automotive Group.
- (Autumn-Winter 2004) Played the part of the basketball in a Fox Sports TV campaign. Fox recorded Downey's voice and actually filmed his mouth, using computer graphics to superimpose it on the ball itself.
- (November 23, 2004) Release of his first album, "The Futurist," by Sony Classical/SBMG Records (SK 92654), and consisting of eight pop ballads written and performed by Downey, and two cover songs, "Smile," written by Charles Chaplin, who was portrayed by Downey in the 1992 biographical film, Chaplin (1992), and "Your Move / Give Peace A Chance" medley, in part derived from the first half of the Yes song "I've Seen All Good People".
- (1992) TV commercial, "Your Vote is Your Voice," with Robert Downey Jr. and Sarah Jessica Parker, and directed by Lawrence Bridges, for Rock The Vote.
- (November 2012) TV commercial for Call of Duty: Black Ops II (2012) video game.
- (March 17, 1989) Guest on "Live on Five".