The former Friends star is often seen in commercials for St. Jude Children's Research Hospital. Her advocacy for St. Jude began in 2008 with their Thanks and Giving Campaign, which featured several celebrities in prime-time TV ads around the Christmas holiday season. Since 2008 Jennifer has been involved with several campaigns for St. Jude including a recent one in which several celebrities remade the Beatles song, “Hey Jude”.
Another charity that Jennifer has been a big supporter of is Friends of El Faro, which improves the lives of children at the Casa Hogar Sion Orphanage in Tijuana. In 2010 Jennifer created the Farita doll in partnership with One&Only Palmilla (a hotel where Jennifer celebrated her birthday in Mexico). The doll was designed and crafted by local artisans and all proceeds were donated to Friends of El Faro.