Alyssa Milano, Isaac Mizrahi, Georgina Chapman, and Anne Fulenwider in Modern Families (2019)

Alyssa Milano and Nina Garcia in Nina Says Don't Cry Over Spilt Silk (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Nina Garcia, and Iris Apfel in Nina Says Don't Cry Over Spilt Silk (2019)

Alyssa Milano, Vanessa Williams, Isaac Mizrahi, Georgina Chapman, and Jasmine Tookes in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Danica Patrick, Wendy Williams, and Lily Aldridge in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, and Georgina Chapman in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Peyton List, and Joan Smalls in Project Runway All Stars (2012)

Alyssa Milano, Carmen Dell'Orefice, Isaac Mizrahi, and Georgina Chapman in Project Runway All Stars (2012)

Alyssa Milano, Jesse Tyler Ferguson, Isaac Mizrahi, and Georgina Chapman in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, and Rebecca Minkoff in Project Runway All Stars (2012)

Alyssa Milano, Tony Danza, Katherine Helmond, and Judith Light in Television (1988)

Alyssa Milano and Arnold Schwarzenegger in Commando (1985)

Alyssa Milano in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, and Andrea Riseborough in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Andrea Riseborough, Irina Shabayeva, Dmitry Sholokhov, Michelle Lesniak, and Anne Fulenwider in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Andrea Riseborough, Evan Biddell, Irina Shabayeva, Dmitry Sholokhov, Michelle Lesniak, and Anne Fulenwider in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Andrea Riseborough, and Irina Shabayeva in All the World's a Runway (2019)

Alyssa Milano, Georgina Chapman, and Dmitry Sholokhov in All the World's a Runway (2019)

Alyssa Milano in Nina Says Don't Cry Over Spilt Silk (2019)

Alyssa Milano in Climate Quick Change (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Reem Acra, and Cynthia Erivo in Climate Quick Change (2019)

Alyssa Milano in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, and Asia Kate Dillon in Project Runway All Stars (2012)

Alyssa Milano, Rose McGowan, and Holly Marie Combs in Charmed (1998)

Alyssa Milano, Rose McGowan, Holly Marie Combs, and Shannen Doherty in Charmed (1998)

Drew Barrymore, Alyssa Milano, Tom Skerritt, Belinda Bauer, Cheryl Ladd, Camilla Belle, Sara Gilbert, Jaime Pressly, Xander Berkeley, Megan Edwards, and Greg Vaughan in Poison Ivy (1992)