Granny, Sylvester, and Tweety travel the globe solving mysteries. Each episode follows a similar format: Granny is invited to an event, a crime is committed, Granny solves it, and Sylvester and Tweety get into trouble.
Pinky and Brain are genetically enhanced laboratory mice who reside in the research facility. Brain is self-centered and scheming; Pinky is good-natured but feeble-minded. In each episode, Brain devises a new plan to take over the world.
A young Xiaolin monk named Omi with a giant yellow head leads a trio of other students to collect powerful items known as Shen Gong Wu while battling the evil Jack Spicer who is also after the artifacts