Top Movies About Disease

by kelseyhill | created - 27 Sep 2016 | updated - 1 month ago | Public
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1. Outbreak (1995)

R | 127 min | Action, Drama, Thriller

65 Metascore

Army doctors struggle to find a cure for a deadly virus spreading throughout a California town that was brought to America by an African monkey.

Director: Wolfgang Petersen | Stars: Dustin Hoffman, Rene Russo, Morgan Freeman, Kevin Spacey

Votes: 103,803 | Gross: $67.82M

2. Contagion (2011)

PG-13 | 106 min | Action, Drama, Sci-Fi

70 Metascore

Healthcare professionals, government officials and everyday people find themselves in the midst of a worldwide epidemic as the CDC works to find a cure.

Director: Steven Soderbergh | Stars: Matt Damon, Kate Winslet, Jude Law, Gwyneth Paltrow

Votes: 211,621 | Gross: $75.66M

3. I Am Legend (2007)

PG-13 | 101 min | Adventure, Drama, Sci-Fi

65 Metascore

Years after a plague kills most of humanity and transforms the rest into monsters, the sole survivor in New York City struggles valiantly to find a cure in this post-apocalyptic action thriller.

Director: Francis Lawrence | Stars: Will Smith, Alice Braga, Charlie Tahan, Salli Richardson-Whitfield

Votes: 654,747 | Gross: $256.39M

4. The Crazies (2010)

R | 101 min | Horror, Thriller

55 Metascore

After a strange and insecure plane crash, an unusual toxic virus enters a quaint farming town. A young couple are quarantined, but they fight for survival along with help from a couple of people.

Director: Breck Eisner | Stars: Radha Mitchell, Timothy Olyphant, Danielle Panabaker, Joe Anderson

Votes: 106,994 | Gross: $39.12M

5. The Bay (II) (2012)

R | 84 min | Horror, Sci-Fi, Thriller

65 Metascore

Chaos breaks out in a small Maryland town after an ecological disaster occurs.

Director: Barry Levinson | Stars: Will Rogers, Kristen Connolly, Kether Donohue, Frank Deal

Votes: 24,162 | Gross: $0.03M

6. Cabin Fever (2002)

R | 93 min | Horror

56 Metascore

Five college graduates rent a cabin in the woods and begin to fall victim to a horrifying flesh-eating virus, which attracts the unwanted attention of the homicidal locals.

Director: Eli Roth | Stars: Jordan Ladd, Rider Strong, James DeBello, Cerina Vincent

Votes: 71,595 | Gross: $21.16M

7. Viral (I) (2016)

R | 85 min | Drama, Horror, Sci-Fi

Following the outbreak of a virus that wipes out the majority of the human population, a young woman documents her family's new life in quarantine and tries to protect her infected sister.

Directors: Henry Joost, Ariel Schulman | Stars: Sofia Black-D'Elia, Analeigh Tipton, Travis Tope, Michael Kelly

Votes: 7,541

8. Contracted (2013)

Not Rated | 84 min | Drama, Horror, Thriller

48 Metascore

After being drugged and raped at a party, a young woman contracts what she thinks is an STD; but, it's actually something much worse.

Director: Eric England | Stars: Najarra Townsend, Caroline Williams, Alice Macdonald, Matt Mercer

Votes: 13,761 | Gross: $0.00M

9. Contracted: Phase II (2015)

Not Rated | 78 min | Drama, Horror, Thriller

35 Metascore

Riley searches for a cure to the virus that took over Samantha before it consumes him and the entire world.

Director: Josh Forbes | Stars: Matt Mercer, Marianna Palka, Morgan Peter Brown, Anna Lore

Votes: 4,141

10. The Andromeda Strain (2008)

180 min | Action, Drama, Sci-Fi

A crack team of top scientists work feverishly in a secret, state-of-the-art laboratory to discover what has killed the citizens of a small town and learn how this deadly contagion can be stopped.

Stars: Benjamin Bratt, Christa Miller, Louis Ferreira, Ricky Schroder

Votes: 13,297

11. The Thaw (2009)

R | 90 min | Horror, Sci-Fi, Thriller

A research expedition to the Arctic discovers that a melting polar ice cap has released a deadly prehistoric parasite.

Director: Mark A. Lewis | Stars: Val Kilmer, Alexandra Staseson, Brad Dryborough, Greg Rogers

Votes: 10,994

12. Carriers (2009)

PG-13 | 84 min | Adventure, Drama, Thriller

Four friends fleeing a viral pandemic soon learn they are more dangerous than any virus.

Directors: David Pastor, Àlex Pastor | Stars: Chris Pine, Piper Perabo, Lou Taylor Pucci, Emily VanCamp

Votes: 40,923 | Gross: $0.09M

13. Doom (2005)

R | 105 min | Action, Adventure, Fantasy

34 Metascore

Space Marines are sent to investigate strange events at a research facility on Mars but find themselves at the mercy of genetically enhanced killing machines.

Director: Andrzej Bartkowiak | Stars: Karl Urban, Rosamund Pike, Dwayne Johnson, Deobia Oparei

Votes: 102,624 | Gross: $28.21M

14. Hidden (I) (2015)

R | 84 min | Horror, Thriller

A family takes refuge in a bomb shelter to avoid a dangerous outbreak.

Directors: Matt Duffer, Ross Duffer | Stars: Alexander Skarsgård, Andrea Riseborough, Emily Alyn Lind, Steven Elliot

Votes: 18,336

15. Right at Your Door (2006)

R | 96 min | Drama, Sci-Fi, Thriller

57 Metascore

A dirty bomb goes off in Los Angeles, jamming freeways and spreading a toxic cloud.

Director: Chris Gorak | Stars: Mary McCormack, Rory Cochrane, Tony Perez, Scotty Noyd Jr.

Votes: 12,477 | Gross: $0.06M

16. Chemical Peel (2014)

R | 95 min | Horror, Thriller

A bachelorette party turns deadly when a chemical reaction overtakes a valley, but being indoors could be just as deadly as being outside.

Director: Hank Braxtan | Stars: Natalie Victoria, Arielle Brachfeld, Stephanie Greco, Lacy Fisher

Votes: 550

17. Blindness (2008)

R | 121 min | Drama, Mystery, Sci-Fi

45 Metascore

A city is ravaged by an epidemic of instant white blindness.

Director: Fernando Meirelles | Stars: Julianne Moore, Mark Ruffalo, Gael García Bernal, Yûsuke Iseya

Votes: 67,539 | Gross: $3.07M

18. Quarantine (2008)

R | 89 min | Horror, Thriller

53 Metascore

A television reporter and her cameraman are trapped inside a building quarantined by the CDC, after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.

Director: John Erick Dowdle | Stars: Jennifer Carpenter, Steve Harris, Columbus Short, Jay Hernandez

Votes: 67,158 | Gross: $31.69M

19. Slither (2006)

R | 95 min | Comedy, Horror, Sci-Fi

69 Metascore

A small town is taken over by an alien plague, turning residents into zombies and all forms of mutant monsters.

Director: James Gunn | Stars: Nathan Fillion, Elizabeth Banks, Michael Rooker, Don Thompson

Votes: 71,350 | Gross: $7.77M

20. Doomsday (2008)

R | 105 min | Action, Sci-Fi, Thriller

51 Metascore

A futuristic action thriller where a team of people work to prevent a disaster threatening the future of the human race.

Director: Neil Marshall | Stars: Rhona Mitra, Bob Hoskins, Alexander Siddig, Caryn Peterson

Votes: 70,423 | Gross: $10.96M

21. Mulberry St (2006)

R | 84 min | Horror, Sci-Fi, Thriller

A deadly infection breaks out in Manhattan, causing humans to devolve into blood-thirsty rat creatures. Six recently evicted tenants must survive the night and protect their downtown ... See full summary »

Director: Jim Mickle | Stars: Nick Damici, Kim Blair, Ron Brice, Bo Corre

Votes: 5,527

22. Splinter (I) (2008)

R | 82 min | Horror, Sci-Fi, Thriller

58 Metascore

Trapped in an isolated gas station by a voracious Splinter parasite that transforms its still-living victims into deadly hosts, a young couple and an escaped convict must find a way to work together to survive this primal terror.

Director: Toby Wilkins | Stars: Shea Whigham, Jill Wagner, Paulo Costanzo, Charles Baker

Votes: 31,881

23. Afflicted (2013)

R | 85 min | Horror, Mystery, Thriller

56 Metascore

Two best friends see their trip of a lifetime take a dark turn when one of them is struck by a mysterious affliction. Now, in a foreign land, they race to uncover the source before it consumes him completely.

Directors: Derek Lee, Clif Prowse | Stars: Clif Prowse, Derek Lee, Michael Gill, Baya Rehaz

Votes: 20,796 | Gross: $0.12M

24. Bite (I) (2015)

Not Rated | 88 min | Horror

57 Metascore

While on her bachelorette party getaway, Casey, the bride to be, gets a seemingly harmless bite from an unknown insect. After the trip, Casey discovers that everything can change with a single bite.

Director: Chad Archibald | Stars: Elma Begovic, Annette Wozniak, Denise Yuen, Jordan Gray

Votes: 3,973

25. Pandemic (2016)

TV-MA | 91 min | Action, Horror, Sci-Fi

47 Metascore

Pandemic is set in the near future, where a virus of epic proportions has overtaken the planet. There are more infected than uninfected, and humanity is losing its grip on survival. Its ... See full summary »

Director: John Suits | Stars: Rachel Nichols, Alfie Allen, Missi Pyle, Mekhi Phifer

Votes: 7,166

26. Containment (I) (2015)

TV-14 | 77 min | Horror, Sci-Fi, Thriller

What happens when an epidemic breaks out, but you're kept in the dark? Anything can happen. Slowly the residents realize that they will all die unless they come together.

Director: Neil Mcenery-West | Stars: Billy Postlethwaite, Louise Brealey, Sheila Reid, Pippa Nixon

Votes: 2,047

27. Cabin Fever 2: Spring Fever (2009)

R | 86 min | Horror

A high school prom faces a deadly threat: a flesh-eating virus that spreads via a popular brand of bottled water.

Director: Ti West | Stars: Rider Strong, Noah Segan, Alexi Wasser, Rusty Kelley

Votes: 12,370

28. Cabin Fever 3: Patient Zero (2014)

Not Rated | 91 min | Horror, Sci-Fi

30 Metascore

When a group of friends enjoying a bachelor cruise in the Caribbean stumble upon a research facility on a remote island, a deadly virus is unleashed. The group must find a way to survive before the flesh eating virus consumes them all.

Director: Kaare Andrews | Stars: Sean Astin, Currie Graham, Ryan Donowho, Brando Eaton

Votes: 6,633

29. The Happening (2008)

R | 91 min | Drama, Mystery, Sci-Fi

34 Metascore

A science teacher, his wife, and a young girl struggle to survive a plague that causes those infected to commit suicide.

Director: M. Night Shyamalan | Stars: Mark Wahlberg, Zooey Deschanel, John Leguizamo, Ashlyn Sanchez

Votes: 189,972 | Gross: $64.51M

30. Condemned (I) (2015)

Not Rated | 83 min | Horror

14 Metascore

Fed up with her parents' bickering, poor-little-rich-girl Maya (Dylan Penn) moves in with her boyfriend who is squatting in an old, condemned building on Manhattan's Lower East Side. With ... See full summary »

Director: Eli Morgan Gesner | Stars: Dylan Penn, Ronen Rubinstein, Genevieve Hudson-Price, Honor Titus

Votes: 980

31. Salvage (I) (2009)

79 min | Horror

When a container washes ashore the residents of a sleepy cul-de-sac are plunged into violence, terror and paranoia. Ring fenced by the military a single mother must overcome all the odds to save her daughter.

Director: Lawrence Gough | Stars: Neve McIntosh, Shaun Dooley, Dean Andrews, Linzey Cocker

Votes: 2,001

32. It Comes At Night (2017)

R | 91 min | Horror, Mystery

78 Metascore

Secure within a desolate home as an unnatural threat terrorizes the world, a man has established a tenuous domestic order with his wife and son. Then a desperate young family arrives seeking refuge.

Director: Trey Edward Shults | Stars: Joel Edgerton, Christopher Abbott, Carmen Ejogo, Riley Keough

Votes: 75,806 | Gross: $13.99M

33. Warning Sign (1985)

R | 99 min | Drama, Sci-Fi, Thriller

A woman working as a security guard in an agricultural research facility finds herself and her co-worker Schmidt fighting to survive against their former friends.

Director: Hal Barwood | Stars: Sam Waterston, Kathleen Quinlan, Yaphet Kotto, Jeffrey DeMunn

Votes: 2,067 | Gross: $1.92M

34. Rabid (2019)

Not Rated | 107 min | Horror, Sci-Fi

43 Metascore

The quiet Rose works in women's fashion clothing, hoping to be a designer. A traffic accident damages her face. She gets experimental stem cell treatment, leaving her stronger and prettier than ever - but there's a side effect.

Directors: Jen Soska, Sylvia Soska | Stars: Laura Vandervoort, Benjamin Hollingsworth, Ted Atherton, Hanneke Talbot

Votes: 2,096



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