- Chilean drug chemist Cockroach brings his product to Colombian smuggler Pablo Escobar. DEA agent Steve Murphy joins the war on drugs in Bogota.
- Steve Murphy is a DEA agent, and along with his new partner, Javier Peña, is assigned the task to eliminate drug threats (by themselves or in conjunction with local law enforcement). They are part of the ground team that executes orders for the Drug Enforcement Administration. Pablo Escobar (Wagner Moura) is connected with a cocaine chemist known as Cockroach from Chile. Together they build their empire, planning and executing new ways of trafficking drugs to and from Cuba and supplying the content to Miami (Florida). After getting betrayed by Cockroach, Pablo takes revenge on him.—Jayanta Patra
- Season one chronicles the life of Pablo Escobar from the late 1970s, when he first began manufacturing cocaine, to July 1992. The show relates the main events that happened in Colombia during this period and Escobar's relationship to them. It is told through the perspective of Steve Murphy, an American DEA agent working in Colombia. The series depicts how Escobar first became involved in the cocaine trade in Colombia. He was an established black marketeer in Medellín, moving trucks worth of illegal goods (alcohol, cigarettes, and household appliances) into Colombia during a time when this was strictly forbidden, when introduced to Mateo "Cockroach" Moreno, a Chilean exile and underground chemist, who pitched the idea that they go into business together, with Moreno producing and Escobar distributing a new, profitable drug-cocaine. They expand beyond Moreno's small cocaine processing lab by building additional, larger labs in the rainforest and, using the expertise of Carlos Lehder, transport their product in bulk to Miami, where it gains notoriety amongst the rich and famous. Soon enough, Pablo develops larger labs and more extensive distribution routes into the United States to supply growing demand. With cocaine's growth into a drug of importance in the American market, one that accounts for a large flow of U.S. dollars to Colombia and escalating drug-related violence in the United States, the Americans send a task force from the DEA to Colombia to address the issue. Murphy is partnered with Javier Peña. The purpose of Murphy's task force is to work with the Colombian authorities, led by Colonel Carrillo, to put an end to the flow of cocaine into the United States. The season ends with Escobar's escape from prison.
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