- Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy's life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex's dead brother Luke.
- A young boy and his father have driven all the way from Winnipeg to Hope Zion Hospital to ask Alex (Erica Durance) to operate on the boys extremely advanced and highly malignant tumour. Alex is determined to help them, but the other surgeons are hesitant to perform such a dangerous and seemingly unrealistic operation. Alex is unwilling to give up, and rallies the troops to attempt the impossible. While Alex focuses on her surgery, Charlie (Michael Shanks) is distracted by the spirit of Alexs brother, Luke (guest star Tyler Hynes, WAREHOUSE 13), who cant move on until Alex lets go of Luke and Charlie lets go of Alex. Meanwhile, Joel (Daniel Gillies) struggles with the many challenges of being Chief of Surgery and between fighting with Shahir (Huse Madhavji) over a controversial Parkinsons study, trying to keep the budget in check, and arguing with Alex over her dangerous surgery, he has his hands full.
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