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A psychotherapist's private life comes apart at the seams when she discovers that her husband is cheating on her. Dr. Dani Santino throws herself fully into her work and soon becomes the most sought-after therapist for celebrity clients.

Michael's quest to find out who killed Diego is interrupted as he helps a widow take on a network of insurance scammers. However, the job could be jeopardized when Madeline befriends an "asset" during the mission.

Michael's job for Gilroy approaches its conclusion, but he is temporarily sidetracked as he is forced to come to the rescue of Fi, who may be in over her head after she takes a job for a violent kidnapper.

An ATF agent is shot by a weapons dealer he was working on. He ends up in a coma and wakes up a few years later. He is told that he is now in the Witness Protection Program and Mary's in charge of him. He asks to see his girlfriend. Mary says she'll do what she can. Raphael's aunt comes for a visit and questions Mary about her plans with Raphael. The agent meets with the prosecutor who tells him that his partner, who at the time of his shooting was addictive to pain killers which made him unconscious when he was suppose to back his partner. So they need his testimony to put the man who shot him away. And it's not a good time for him to see his girlfriend. After he leaves, the prosecutor tells everyone including Mary that his partner and girlfriend are now married. They try to convince him to wait after the trial but he bolts to see her.

Mary and Marshall try to help FBI Agent Mike Faber convince his informant to enter WITSEC. Despite their best efforts, the informant refuses their protection and gets himself into a heap of trouble. After Mary, Marshall and Agent Faber save the informant from certain death, he and his family join Witsec. Meanwhile, Stan has to deal with an ex-boxer/witness suffering from pugilistic dementia.

When Mary's new witness, Dominic, a socio-pathic former hit man with a love of explosives, falls in love for the first time, Mary hopes he will finally have a shot at normalcy and redemption. Unfortunately, it all goes pear shaped when his would-be-girlfriend, Naomi, breaks Dom's heart. Mary races to stop Dominic from taking out his pain in the form of an explosive device meant for Naomi. Meanwhile Mary deals with her own regrets after her break up with Raph.

When a hardened bank robber who's been in Witsec in prison for decades is finally paroled, it falls to Mary to help him acclimate to life on the outside and keep him from falling back into a life of crime. Meanwhile, when one of Mary's other witnesses becomes the victim of a revenge plot, Marshall steps in to help out -- only to find himself in a predicament when the witness prefers him to Mary.

As Michael prepares for his meeting with John Barrett, he also agrees to help a sleazy defense attorney whose daughter has been kidnapped, while Fi and Madeline try to convince Jesse not to kill Michael for burning him.

A thief blackmails the gang into helping her get a chemical weapon back from the Venezuelans who stole it, and Jesse turns to Marv, his former handler, to help Michael get his hands on the Bible.

Jesse convinces Michael, Sam, and Fi to help a warehouse security guard being harassed by mobsters. But when Michael's cover is compromised, Sam is forced to take over and run point in the operation.

While Michael and Fi try to foil the heist of a priceless antique sword, Sam and Jesse try an interrogation trick to get information out of Kendra.

Michael helps a former Cold War spy who has been targeted by Russian operatives, while Fi helps Jesse get a chance to speak with his old boss about who burned him.

After a short stint back in prison, Neal, though still shaken by Kate's death, re-partners with Peter to catch a suave but arrogant bank robber.

At a winery, HankMed deals with a young owner apt to sudden onsets of sleep and an uninsured wine taster gobbling pain pills. Evan discovers a personal talent.

While Hank helps out a food truck owner who displays strange, antisocial behavior, Evan is a "faux beau" for a young woman who doesn't want her parents to know she's dating a much older photographer.

While Evan gets roped into a hunting trip, playing "faux beau" again to impress Paige's parents, Hank discovers that his new young patient's mother is a familiar face from Hamptons Heritage.

Hank treats a lottery winner with hand trouble, and a kidney transplant recipient with pain and stomach issues, while suspecting a sly purpose behind Eddie's party.

Shawn and Gus find themselves caught between two rival Chinese Triad families as they search for one of the leader's abducted daughter. Meanwhile, Shawn's father Henry joins the police department in charge of the "consultants"--Shawn and Gus. Juliet also deals with her lingering trauma.

Unhappily, the FBI forces Neal to work with the insurance investigator who once spoke against him at his trial and got him convicted.

Mozzie turns to Neal and the Bureau for help when his intellectual waitress girlfriend is in trouble.

New CIA recruit Annie Walker is brought in to retrieve secrets from a Russian spy seeking asylum, but he is assassinated by a sniper before the exchange can be finished.

Neal and the bureau set their sights on bringing down an adoption lawyer extorting adoptive clients to cover his gambling debts.

Annie tries to reach out and protect a mother and son after the son uncovers a coded IRA message.

Annie discovers that the wife of a U.S. senator is selling secrets to the Indonesians and is planning to frame the senator's chief of staff, with whom he is having an affair.

After a routine briefcase exchange at a Swiss airport goes wrong, Annie is stuck at a safe house with a Mossad officer whom she's not sure she can trust.