Des années après qu'une épidémie a anéanti presque tous les êtres humains et transformé le reste en monstres, le seul survivant à New York se bat pour trouver un remède.
McCall meets an old Agency colleague who now hires himself out as a killer. His next target is an ambassador and his wife. He asks for McCall's help to save the wife because she is a woman they both used to love.
Michaela and Ben put everything on the line to attempt a daring rescue; As the final hours of Zeke's life approach, Saanvi and Vance make a last-ditch effort to appeal to the Major, who may be the only person who can save him.
