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The Monolith Monsters (1957)
One of the few Science Fiction films to ever remain fully plausible from beginning to end.
I must admit that the chemistry involved in this film is a little vague but for the period, it leaves room for explanations that would fill in the gaps. This story was conceived decades before the concept of nano-technology (self-replicating molecular machines) and years before the first viable discussion of prions (endlessly self-replicating proteins). It is clear that Michael Crichton was inspired by this film for his story "The Andromeda Strain" although he would have argued the point to death in court (he was good at that). I have nothing but respect for the authors of the screenplay, Norman Jolley and Robert Fresco, and the director, John Sherwood. In an age that was dominated by giant atomic critters and hostile aliens, this is a stand alone item with the protagonists fighting a unique menace with clear thinking. Please notice that the scientists and the journalist are heroes and not the villains. I saw this film in the late 60's on the Saturday Matinée Creature Feature. I never forgot it. I was ecstatic to find that it had been released on DVD, FINALLY! More than 30 years was far too long to see this movie again.