It's got interesting plots which even I can understand (most of the time anyway), and the only medicine I know is paracetamol - you don't need to be a medic to like it! It's got interesting story lines, including a couple of love lines; however, they don't get in the way of the show.
Hugh Laurie (Dr. Gregory House) is fantastic; he is funny in the sarcastic way and, let's face it, he is number 10 in the 10 sexiest men according to one of the magazines. House believes that all patients are lying, that it's normal to be selfish and that happy families don't exist.
Other doctors, particularly Dr. Cameron (the name of the actress escapes me) are the opposites of House - trusting and making choices based on morals (picking rarer disease instead of a more common one that however can only be caused by adultery of the patient, etc). The final decision is often up to House, and is almost always right, if not the first time round.
Even the music in the opening is brilliant, Teardrop by Massive Attack, and the show will keep you on your toes, except for those hundreds of moments in each episode which will make you smile and perhaps 10 or 20 moments that will make you laugh out loud. Enjoy! 10 out of 10, without any doubt.