| 11:35 PM | Late Show With David Letterman: Actress Sigourney Weaver; sportscaster Marv Albert; Julian Casablancas performs. |
| 12:37 AM | The Late Late Show With Craig Ferguson: Actor Ray Romano; Nellie McKay performs. |
| 1:37 AM | Comics Unleashed With Byron Allen: Ron Pearson; Todd Glass; Kathleen Madigan; Dean Edwards. |
| 2:07 AM | Profit In Your Town: Profit In Your Town. |
| 2:37 AM | Fast Cash |
| 3:07 AM | Relieve Back Pain: The Back2Life machine, your Personal Pain Therapist, relieves chronic back pain in 12 minutes a day! |
| 3:37 AM | Up to the Minute: Film reports are used to launch studio debates on a variety of subjects. |
| 4:30 AM | CBS Morning News: News reports on current events. |
| 5:00 AM | Local Programming |
| 7:00 AM | The Early Show: The first PGA Tour event of 2010; personal finances; fitness. |
| 9:00 AM | The Doctors: Beauty tips for moms on a budget; the do's and don'ts of giving a massage. |
| 10:00 AM | Let's Make a Deal: Costumed contestants compete for cash and prizes. |
| 11:00 AM | The Price Is Right: Contestants bid for prizes. |
| 12:00 PM | Local Programming |
| 12:30 PM | The Young and the Restless - Billy Makes Malcolm an Offer: Chance is determined to figure out who is targeting him; Jo-Jo refuses a DNA test. |
| 1:30 PM | The Bold and the Beautiful: Furious Bill Spencer issues the Forresters an ultimatum; Steffy confesses to her family. |
| 2:00 PM | As the World Turns: Paul discovers Emily passed out; Parker and Sage try to get Jack and Carly back together. |
| 3:00 PM | Dr. Phil: Dr. Phil reveals the eight non-negotiable rules all married couples must follow to fight fair. |
| 4:00 PM | Judge Judy: A woman sues her son's half brother for the cost of a plane ticket to Jamaica. |
| 4:30 PM | Judge Judy: A man sues his former girlfriend for rent, utilities and late fees. |
| 5:00 PM | Local Programming |
| 6:30 PM | CBS Evening News With Katie Couric: The latest world and national news. |
| 7:00 PM | The Insider |
| 7:30 PM | Entertainment Tonight: Coverage of the 2010 People's Choice Awards. |
| 8:00 PM | CSI: Crime Scene Investigation - Kill Me if You Can: The team investigates three different cases in one night that seem to be unrelated. |
| 9:00 PM | CSI: Crime Scene Investigation - No Way Out: Riley and Langston are taken hostage after a shootout in a normally quiet Las Vegas community. |
| 10:01 PM | The Mentalist - Red Menace: The CBI team encounters one of California's most dangerous motorcycle gangs. |
| 11:00 PM | Local Programming |
| 11:35 PM | Late Show With David Letterman: Actor Bradley Cooper; Nick Jonas and the Administration perform. |