As Lloyd and company visit the twin world of Tethe'alla to search for a cure to Colette's disease, Angel Toxicosis, they meet her counterpart Chosen One, Zelos, who has an agenda of his own.
As Colette's fate becomes more complicated, Lloyd gains a new ally in Regal Bryant, the former president of a conglomerate who had until recently been imprisoned for murder.
Former assassin and current ally Sheena may be the key to defeating their enemy by forming a pact with a powerful spirit, except the last time she did it.
Lloyd and his comrades make an assault on the "Nest of Flying Dragons" in an attempt to rescue Colette, but aside from an army of dragons and a behemoth-sized dragon, Lloyd's master swordsman father stands in his way.
As the journey's end nears, a pact with a powerful spirit must be broken while Lloyd and his comrades race to the top of the Tower of Salvation to stop their true enemy once and for all.