The film is dedicated to the memory of crew member Craig Priestley who passed away after production.
The titular hotel is a mix of on location shooting and two working hotels and purpose based sets.
Director Ed Greenberg describes The Renata Road (2022) as "if Lost Highway (1997), Lost in Translation (2003) and The Exterminating Angel (1962) were to procreate, this film would be their bastard offspring".
Sharon Sinclair was also in Sherlock Holmes: The Dancing Men (2022) executive produced by The Renata Road (2022) director Ed Greenberg.