The phrase "First born Unicorn" refers to Dorothy Stratten, whose life was covered in the book The Killing of the Unicorn.
The song begins in the key of A minor with Frusciante picking the chords of Am and F for twelve measures, before picking the chords of C-G-F-Dm then going back and picks Am and F for 8 more measures before picking C-G-F-Dm again.
The music video is similar to some games that were mostly sandbox/open world based game-play.
The music video for "Californication" is the group's most watched on YouTube, with over 366 million views.
"Californication" has remained one of the band's most popular and most performed live songs appearing in almost every set-list since its live debut making it the band's third most performed song with over 500 performances.