Watson is implicated in a DEA investigation into doctors writing illegal prescriptions, so she and Holmes look for the culprit using her medical license to sell drugs.
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Watson goes through a list of phone numbers Marla called and one stands out as "weird" to him - "929 555 0196" in "Queens, NY", circling it - recognized as her having called it two weeks prior. More weird is not only did every non-blocked number have a 555 prefix, typical of television and usually not worthy of note, but was also always followed by 01. Holmes recognizes the number by its "prefix" as being a private exchange. Again, every prefix was the standard fake prefix "555", so not as insightful of an observation worthy of Sherlock Holmes to make. See more