Spider-Man and the Web Warriors have been informed by Vulture that there is a spy in S.H.I.E.L.D academy. During a training session conducted by Agents Fitz and Simmons, the Web Warriors try to question the students about one of them being a spy, they deny any involvement with Doctor Octopus. The Web Warriors begin to suspect Dr. Connors of being a spy for Doctor Octopus, due to him becoming the Lizard earlier. Spider-Man refuses to believe Dr. Connors is the spy. However, when Spider-Man and the Web Warriors try to question Connors, they discover that he has turned into the Lizard again. Only this time the Lizard has gained a new ability by infecting everyone at the Triskelion with his infectious bite. Spider-Man must contain the lizard outbreak before it spreads out of the Triskelion and he must figure out who has turned Connors into the Lizard.
—dawsonpersi