In this episode, Taylor Lautner deals with a patient who has "werewolf syndrome". Lautner first gained major stardom for starring in Twilight (2008) and its sequels as Jacob, who was a werewolf.
The doctor at the start of the episode, Dr. Mike, who is played by Jerry O'Connell, also starred in Scream 2 (1997) as Derek, who was studying at college to be a doctor. The original title of Scream 2 was also "Scream Again".
Jerry O'Connell - who plays Dr. Mike in flashbacks - is married to Rebecca Romijn, the former wife of John Stamos, who stars as Dr. Brock Holt.
There is no mention of Grace, played by Skyler Samuels, in the first season. In reality, she left the show to focus on her education.
The second season was initially going to take place at a summer camp. When another summer camp horror series named Dead of Summer was announced before production began, they quickly changed the location to a hospital. The summer camp setting was later used for the ninth season of American Horror Story, which also starred Emma Roberts and Billie Lourd.