In the background, Coulson has the ax that Mack used to cut off his hand hanging on the wall in his office.
It was announced that Season 3 of Agents of S.H.I.E.L.D. will introduce the Secret Warriors to the Marvel Cinematic Universe, assembled by Director Coulson and led by Daisy Johnson (Skye).
Chloe Bennet had to have her hair cut for this season to go along with the comic book version of Daisy Johnson. However, they went with a more fashion-forward style than in the comics.
This is the first episode to come out after Ant-Man (2015) and has a reference to the "Pym Technologies" disaster from that movie.