Willis must help a promising soccer player make a life-altering decision after he's seriously injured, and another patient's hesitation to share that she's transgender makes it difficult for the doctors to diagnose her severe abdominal pain.
Willis defies Campbell's orders when he helps Mario and Heather perform a radical procedure on a maintenance worker stuck under a boiler that exploded. Also, Angus' father, Dr. Desmond Leighton (Steven Culp), tries to seize Power of Attorney over Mike, who is still in a coma, even though Mike granted that right to his brother, Angus.
The Angels Memorial doctors treat victims caught in a landslide, and a group of children come in from a camping trip with measles putting the entire ER at risk. Meredith Baxter and Eric Roberts guest star.
When a police officer arrives at the emergency room with an explosive bullet stuck in her leg, a risky operation is needed to be performed by Wills, Leanne and Jesse; a magician having difficulty breading comes to Angel's memorial for help.
The doctors must treat Campbell's 13 year old daughter when she arrives at the hospital after a seizure caused by spina bifida; a deaf work addict and her translator seek medical assistance ate their car rolls over into the Los Angeles River.