Toronto 1869. Sherman and Peabody meet Constable Archibald Willy, who is pursuing Wanted woman Ottowa O'Toole. Sherman and Peabody's ruse to trap O'Toole backfires and she kidnaps them. But, they are quickly rescued, and Ottowa is caught.
New York City - 1824. Audubon cannot finish painting portraits for his book on birds because of a bird thief. Sherman and Peabody play detective in order to discover and capture the chicken-napper.
In 1914 England, Mata Hari has stolen the plans to Britain's greatest secret. Peabody and Sherman must capture her before she turns those plans over to the Germans.
Mr. Peabody and his boy Sherman travel to ancient Egypt in the year 42 B.C., where they help Queen Cleopatra regain her throne from her evil brother, Prince Ptolemy.