It is revealed that Lola is not just the name of Coulson's 1962 red Corvette, but also an acronym which stands for Levitating Over Land Automobile.
Skye says she has ended up on the "DL" and has to explain that this means "disabled list". At the time of the first broadcast, this term was used by Major League Baseball for players who were injured and temporarily removed from the roster. It was unique to MLB, in that all other sports leagues used the term "injured list", and MLB changed to using that term in 2019. To know this term and use the common shorthand abbreviation "DL" indicates that Skye is more than a casual fan of baseball in the US.
The title is a reference to the novel "Love in the time of cholera" by Gabriel Garcia Marquez.
"Love in the Time of Hydra" originally aired on ABC on March 24, 2015, and according to Nielsen Media Research, was watched by 4.29 million viewers.
Kirk Acevedo plays Agent Calderon, who works for Robert Gonzalez, played by Edward James Olmos. Olmos played Lt. Castillo on Miami Vice (1984). In that series, the original villain was named Calderone, but that was before the arrival of Castillo.