The real life plastic surgeon, who is supposedly a spoof of Dr. Franff, (Dr. Fredric Brandt) who is played by Martin Short, committed suicide on April 5, 2015. It is rumored that because the show over-exaggerates the looks of Dr. Brandt, and the harsh media attention he received, this is one of the potential reasons that led to his suicide.
When Kimmy brings in a discarded TV from the curb, Titus jokingly calling Kimmy "Ariel." This is a reference both to her red hair and to the fact that Tituss Burgess played the role of Sebastian the Crab in the original Broadway cast of the stage version of Disney's The Little Mermaid.
The Broadway play Spiderman 2 is a reference to the failed Broadway Spiderman show that had numerous injuries before closing before opening.