Yachiyo Inugami is a dog-like person who loves cats whilst Suzu Nekoyama is a cat-like person who loves dogs. Upon being introduced to each other by their mutual friend, Aki Hiiragi, the two take an instant interest in each other.
Yachiyo gets to know her classmate, Mikine Nezu, who displays a lot of mouse-like tendencies. Later, Mikine takes Yachiyo and Suzu to the biology club to meet her upperclassman, Yukiji Ushikawa, who is much like a cow.