When Francine shows up at the CIA to find Stan, she crashes into the front of the building in the same way Stan does at the end of the opening credits.
When Stan is about to sleep with his boss at the end, the song that is playing in the background is Sade's "No Ordinary Love".
During WWII there was actually a plan to use drugs to turn Hitler into a woman.
The theory behind it was much the same as the theory behind the fictional pill in the episode, woman are better listeners, less aggressive, and more emotionally open.
(It would not have worked.)