Leslie mentions that she made Ann 103 scrap books; this episode is the 103rd episode in the series.
Scrapbook titles that Leslie has made for Ann include, among others: Thoughts on Sam Waterston; Nurse Ann; Eat, Read "Eat Pray Love," Talk; The Mystery of the Woman We Saw in Food and Stuff Who Looked Like Isla Fisher; First Text Message; Road Trips 100 Miles or More; The Breakfast Album; Halloween; Kelly Clarkson Concerts 1, 2 & 3; Galentine's Day; and Pregnant!
There is a scene where Chris Traeger (Rob Lowe ) wears a JFK mask in Ann's going away party and says a line from President Kennedy's inauguration speech. Rob Lowe played JFK in the movie Killing Kennedy (2013).
April tells Ann that Michigan has wolverines and maybe they will eat Ann's toes. The first ever SNL sketch features a person teaching English to an immigrant. One of the lines is "I would like to feed your fingertips to the wolverines."