In this first of a four part story, Spider-Man, the Avengers and the Agents of S.M.A.S.H. battle their greatest foes for the fate of the planet. In the first round Spider-Man is chosen to be part of The Collector's team and is partnered with Hulk and Iron Man against The Grandmaster's team of villains consisting of Kraven, Molten Man and The Wendigo King.
In the first part of the story, Spider-Man has noticed that everyone is disappearing; he has to help the Collector defeat his brother the Grandmaster in the Contest of Champions. The Collector and Spider-Man have to select the heroes and the Grandmaster selects the villains in the game. Spider-Man enlists Iron Man and Hulk to defeat Kraven, the Wendigo King, and Molten Man in the first round.