Several of the actors on Kindred also had guest roles in Buffy: The Vampire Slayer and its spin-off series Angel. Brian Thompson, Channon Roe, and Jeff Kober all appeared in various episodes of Buffy, and Brigid Walsh appeared on Angel.
Kindred: The Embraced is based on the White Wolf pencil-and-paper RPG series Vampire: The Masquerade. The vampire clans, rules of the Masquerade and Blood Hunts, cities ruled by vampire princes, etc., are all taken from the mythology of the RPG, which is set in White Wolf's World of Darkness; a skewed, darker, mystical version of our reality where vampires, werewolves, magicians, etc. all exist but hide themselves from humans.