Andre' Joseph and Aesha Waks had briefly worked together for one scene on the former's first film, Priceless. Aesha was cast in Night Stream based on the chemistry they had on the previous film.
Originally written as an anthology feature about the radio show's listeners before it was cut down into a short film.
Reginald L. Barnes was the last actor to audition for "Eddie".
The radio voice of "Phil" is played by Jeff Gallashaw, co-host of the popular online movie review show, The Cinefiles, which Andre' Joseph was a frequent guest on.