Several regulars or guest stars on this show were also regulars on The West Wing, another series about the inner workings of US government. These include: John Goodman (Senator Gil John Biggs on Alpha House; Speaker of the House/President Glenallen Walken on The West Wing), Janel Moloney (Senator Peg Stanchion on Alpha House; White House staffer Donna Moss on The West Wing),and Bradley Whitford (Senator Ned on Alpha House; Josh Lyman on The West Wing),
Cynthia Nixon (Senator Carly Armiston) and Matt Malloy (Senator Louis Laffer) were also both cast member in two of the other politically themed TV series that Garry Trudeau has helped to create: "Tanner '88" and "Tanner on Tanner".
Janel Maloney plays a senator from North Dakota in Alpha House. In West Wing as Donna Moss,aide to White House Deputy Chief of Staff Josh Lyman, she is sent to represent the White House also in North Dakota during a conference to eliminate the word North from the state's name.