As Red (James Spader) enlists activist whistleblowers in his search for the mole, Liz (Megan Boone) pursues a deranged scientist who's helped dozens of criminals escape by engineering and killing their genetic doubles.
The Pavlovich brothers specialize in abductions of high value targets and according to Red, they are planning their next hit. While the team tries to protect the next target, Red has a job of his own for the Pavlovich Brothers. Elsewhere, Liz patiently tries to uncover the truth about Tom.
After a politician in Prague is framed for a murder, Red suspects it's the work of The Kingmaker - a strategist behind the rise of some of the world's most powerful politicians. While Red helps Liz and the FBI catch him, Liz uncovers a secret that Red's been keeping from her.
Liz refuses to work with Red after discovering the truth about the death of her father. Seeking to make amends and force Liz to see him, Red brings the FBI a case they can't ignore. Meanwhile, Liz reveals what she knows about Tom's secret life to the FBI.
With the crashing of the mysterious prisoner transport plane, the city is on lock down as the authorities are on the hunt for all the escapees. Meanwhile, with Red in custody, Liz uses her power to get him out since he is their best chance at finding all the suspects. Elsewhere, their main objective is to track down Berlin, a prisoner on the plane who is somehow involved.
Red continues to battle Berlin and faces a new threat from a man named Lord Baltimore. An important person comes back from the past into Red's world. Meanwhile, Liz tries to move forward with her life after her showdown with Tom.
When the Monarch Douglas Bank is robbed, Red seizes the opportunity to try and take the money-laundering bank down. Liz questions Red's intentions as she investigates the crime. Meanwhile, a new member joins Cooper's taskforce after impressing everyone on the team.
When a man is found with his heart cut out, Agents Keen and Ressler team up with agent Samar Navabi to uncover the intricacies of Dr. Covington's black-market operation. Meanwhile, Red and his associate try to capitalize on a new opportunity in Indonesia, leaving Reddington in a vulnerable position.
After a series of seemingly nonviolent citizens become killers, Red tips off Liz that a dangerous social-psychological experiment may be underway. Elsewhere, Red tries to convince Naomi and her husband into accepting a complicated proposition.
Agents Keen, Ressler and Cooper pursue an eco-terrorist cell in search of a destructive weapon. Meanwhile, Liz tries to lose her guardian. Elsewhere, Red uses manipulation to pursue someone close to his heart.
When an Iranian nuclear scientist is suspiciously assassinated, a revenge ploy begins against a valued American. Red informs agents Keen and Navabi that a dangerously conniving hitman "The Scimitar" has been sent to the job. Liz and Ressler find themselves in a tricky predicament as they investigate a surveillance lead. Agent Keen attempts to gather information on Berlin, while Red finds company with a woman working at a food truck.